Evidence map›Paper›PMID 41867848›Full record

ArticlebioRxiv : the preprint server for biology2026

Molecular Transducers of Physical Activity Consortium (MoTrPAC): Initial Insights into the Dynamic Human Responses to Exercise.

MoTrPAC Study Group, Anna R Brandt, Jerome Fleg, Bret H Goodpaster, Byron Jaeger, Christopher A Jin, Neil M Johannsen, Dan Katz, Hasmik Keshishian, Wendy M Kohrt and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

MoTrPAC Study Group
Anna R BrandtBall State University, Muncie, IN.ORCID 0009-0002-3498-7408
Jerome FlegNational Institutes of Health, Bethesda, MD.
Bret H GoodpasterAdventHealth, Orlando, FL.ORCID 0000-0003-1275-5147
Byron JaegerWake Forest University, Winston-Salem, NC.
Christopher A JinStanford University, Stanford, CA.ORCID 0000-0001-7340-5023
Neil M JohannsenPennington Biomedical Research Center, Baton Rouge, LA.ORCID 0000-0003-4905-4491
Dan KatzStanford University, Stanford, CA.
Hasmik KeshishianBroad Institute of MIT & Harvard, Cambridge, MA.ORCID 0000-0002-0062-9867
Wendy M KohrtUniversity of Colorado Anschutz Medical Campus, Aurora, CO.
William E KrausDuke University, Durham, NC.ORCID 0000-0003-1930-9684
Bridget LesterBall State University, Muncie, IN.
Edward L MelansonUniversity of Colorado Anschutz Medical Campus, Aurora, CO.ORCID 0000-0001-9151-9745
Michael E MillerWake Forest University, Winston-Salem, NC.ORCID 0000-0002-3903-6655
Samuel MontalvoStanford University, Stanford, CA.ORCID 0000-0003-3104-3428
W Jack RejeskiWake Forest University, Winston-Salem, NC.
Samiya M ShimlyStanford University, Stanford, CA.ORCID 0000-0002-0215-499X
Gregory R SmithIcahn School of Medicine at Mount Sinai, New York City, NY.ORCID 0000-0003-0112-6134
Cynthia L StoweWake Forest University, Winston-Salem, NC.ORCID 0000-0002-1887-3294
Scott TrappeBall State University, Muncie, IN.ORCID 0000-0002-6438-431X

Funding

PAGES: Physical Activity Genomics, Epigenomics/transcriptomics SiteU24DK112331 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2022 to 2025
$12.7M
NIDDK NIH HHS U24 DK112331
6 · The paper itself

Abstract

The goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to examine the physiological and molecular basis for health benefits in response to acute and chronic exercise. Prior to COVID-19 suspension, healthy, sedentary participants (N=206, 18-74y) were randomized to endurance exercise (N=80), resistance exercise (N=81), or non-exercise control (N=45) interventions. The prescribed vigorous acute endurance and resistance exercise bouts induced physiological and metabolic perturbations relative to resting homeostasis. The supervised chronic (3d/wk, 12wk) endurance or resistance training programs robustly improved several physiological parameters (i.e., VO

Indexed as

AdiposeBloodEnduranceMuscleResistanceStrengthTraining

Identifiers

PMID41867848
PMCPMC13001330

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.