Evidence map›Paper›PMID 41867912›Full record

ArticleProceedings of machine learning research2025

Integrating Social Determinants of Health in a Multi-Modal Deep Clustering Survival Model for Injury-Risk in Alzheimer's and Related Dementia Patients.

Kazi Noshin, Mary Regina Boland, Bojian Hou, Weiqing He, Victoria Lu, Li Shen, Aidong Zhang

Abstract read
In one paragraph

Article in Proceedings of machine learning research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Expert-Driven Survival Machines: Improving Stratification and Interpretability in Multiple Clinical Cohorts.ACM-BCB ... ... : the ... ACM Conference on Bioinformatics, Computational Biology and Biomedicine. ACM Conference on Bioinformatics, Computational Biology and Biomedicine · 2026
    Article
  2. Multi-Modal Deep Clustering Survival Machines for Alzheimer's Disease Subtype Discovery.... IEEE International Conference on Computer Vision workshops. IEEE International Conference on Computer Vision · 2025
    Article
  3. Determining the Importance of Clinical Modalities for NeuroDegenerative Disorders and Risk of Patient Injury Using Machine Learning and Survival Analysis.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kazi NoshinDepartment of Computer Science, University of Virginia.
Mary Regina BolandData Science Program, Department of Mathematics, Saint Vincent College, Latrobe, PA 15650, USA.
Bojian HouDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Weiqing HeDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Victoria LuDepartment of Computer Science, University of Virginia.
Li ShenDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Aidong ZhangDepartment of Computer Science, University of Virginia.

Funding

Technology Identification and Training CoreP30AG073105 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DEMIRIS, GEORGE, KARLAWISH, JASON H · 2021 to 2025
$21.2M
Ultrascale Machine Learning to Empower Discovery in Alzheimers Disease BiobanksU01AG068057 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christos Davatzikos, Heng Huang · 2020 to 2026
$20.7M
Artificial Intelligence Strategies for Alzheimer's Disease ResearchU01AG066833 · NIA · CEDARS-SINAI MEDICAL CENTER · PI MOORE, JASON H., RITCHIE, MARYLYN D · 2022 to 2025
$6.7M
Translational big data analytic approaches to advance drug repurposing for Alzheimer's diseaseR01AG071470 · NIA · UNIVERSITY OF PENNSYLVANIA · PI KIM, DOKYOON, NING, XIA · 2021 to 2025
$3.8M
NIA NIH HHS P30 AG073105NIA NIH HHS R01 AG071470NIA NIH HHS U01 AG066833NIA NIH HHS U01 AG068057
6 · The paper itself

Abstract

As our population ages, the prevalence of Alzheimer's Disease and Related Dementias (ADRD) and its associated burdens continue to rise. Social Determinants of Health (SDOH) significantly influence both ADRD development and progression. Using Electronic Health Records (EHR) from a quaternary care academic medical center in a diverse urban setting, we investigated SDOH's impact on multi-modal deep clustering survival machines. Our findings revealed that SDOH improved model performance across feature selection methods (DeepCox roll-out vs. SHAP DeepExplainer) and EHR clinical modalities (medication vs. laboratory). Additionally, Laboratory features proved more informative than medications for predicting injury-fall risk. Our results highlight SDOH's crucial role in ADRD progression, particularly regarding injury-fall risk. We found that feature importance varied by selection method when analyzing multi-modality EHR data, with education emerging as a key SDOH factor among our top 10 features, underscoring its significance in ADRD progression.

Identifiers

PMID41867912
PMCPMC13004619

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.