ArticleDrug design, development and therapy2026
Determination of ED50 and ED95 for Ciprofol in Morbidly Obese Patients During Induction of General Anesthesia: A Single-Center, Up-and-Down Study Based on Lean Body Weight.
Article in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Obesity alters the pharmacokinetics and pharmacodynamics of hypnotic agents; however, dose-finding data for ciprofol during the induction of general anesthesia in morbidly obese adults remain limited. We estimated the lean body weight (LBW)-scaled 50% effective dose (ED50) and 95% effective dose (ED95) of ciprofol for loss of consciousness by using an up‑and‑down sequential design. Methods: This prospective single-center trial enrolled adults aged 18-65 years with morbid obesity who underwent elective surgery. Ciprofol was administered as a slow intravenous bolus at an initial dose of 0.76 mg kg Results: Thirty-six patients were included in the study. The sequence yielded either successful or failed crossovers. The LBW-scaled ED50 and ED95 of ciprofol for loss of consciousness were 0.492 mg kg Conclusion: The LBW-scaled ED50 and ED95 of ciprofol for loss of consciousness during the induction of general anesthesia in morbidly obese adults were 0.492 and 0.634 mg kg
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