Evidence map›Paper›PMID 41868456›Full record

ArticleTranslational research in anatomy2025

Aberrant placental structure is corrected with repeated nanoparticle-mediated IGF1 treatments in a Guinea pig model of fetal growth restriction.

Baylea N Davenport, Rebecca L Wilson, Alyssa A Williams, Jaimi A Gray, Edward L Stanley, Helen N Jones

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational research in anatomy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Genetics and Stillbirth.Clinics in perinatology · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Baylea N DavenportCenter for Research in Perinatal Outcomes, College of Medicine, University of Florida, Gainesville, FL, USA.ORCID 0000-0001-5804-2340
Rebecca L WilsonCenter for Research in Perinatal Outcomes, College of Medicine, University of Florida, Gainesville, FL, USA.
Alyssa A WilliamsCenter for Research in Perinatal Outcomes, College of Medicine, University of Florida, Gainesville, FL, USA.
Jaimi A GrayFlorida Museum of Natural History, University of Florida, Gainesville, FL, USA.
Edward L StanleyFlorida Museum of Natural History, University of Florida, Gainesville, FL, USA.
Helen N JonesCenter for Research in Perinatal Outcomes, College of Medicine, University of Florida, Gainesville, FL, USA.

Funding

Placental-specific therapy for fetal growth restrictionR01HD090657 · NICHD · UNIVERSITY OF FLORIDA · PI HELEN N JONES · 2017 to 2026
$2.6M
NICHD NIH HHS R01 HD090657
6 · The paper itself

Abstract

Background: Fetal growth restriction (FGR) is most commonly due to placental insufficiency. There are currently no treatments for placental insufficiency or FGR, and the only intervention is iatrogenic pre-term delivery. We have previously shown efficacy of repeated placental nanoparticle-mediated Methods: Here we investigate the structural remodeling of the placenta in a maternal nutrient restriction (MNR) guinea pig model following 3 repeated intraplacental injections of nanoparticle-mediated Results: Sham-treated MNR placentas displayed disorganized microvasculature labyrinthine exchange areas with a reduction in placental capillary number and an increase in the volume of the placenta macrovasculature. Repeated nanoparticle-mediated Conclusions: This data demonstrates repeated nanoparticle-mediated

Indexed as

Fetal growth restrictionGene therapyNano-CTNanoparticlePlacental structureVascular remodeling

Identifiers

PMID41868456
PMCPMC13003953

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.