ArticleFrontiers in neurology
The role of fear of relapse in quality of life among patients with relapsing-remitting multiple sclerosis.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Relapsing-remitting multiple sclerosis (RRMS) is characterized by unpredictable relapses that affect neurological and psychological functioning. Among psychosocial factors, fear of relapse (FoR) has been increasingly studied in relation to quality of life (QoL). This study examined the associations of FoR and health anxiety with QoL in RRMS. Methods: In this cross-sectional study, 94 RRMS patients and 50 demographically comparable healthy controls were included. Participants completed the Expanded Disability Status Scale (EDSS), FoR Scale, Health Anxiety Inventory (HAI-18), and Short Form-36 (SF-36). Between-group comparisons were conducted for descriptive purposes. Correlation and hierarchical regression analyses were restricted to the RRMS group. Results: Compared with healthy controls, RRMS patients had higher health anxiety and lower physical and mental QoL scores (all Conclusion: FoR and health anxiety are significantly associated with QoL in RRMS. While health anxiety demonstrated comparatively stronger associations, FoR was also related to QoL beyond demographic and clinical variables, supporting the clinical relevance of both general and disease-specific anxiety processes.
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