ArticleJournal of acute medicine2026
Clinical Characteristics and Factors Associated With Critical Illness and Mortality in Patients Hospitalized With COVID-19: A Retrospective Cohort Study in Taiwan.
Article in Journal of acute medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Emergency Departments as Early Clinical Sentinels and the Final Operational Buffer.Journal of acute medicine · 2026Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: The ongoing COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to significant morbidity and mortality worldwide. Identifying the clinical features and factors influencing severe disease and mortality in individuals hospitalized with COVID-19 is essential for informing clinical management strategies and optimizing healthcare resource distribution. Methods: We conducted a retrospective cohort study of 684 patients hospitalized with COVID-19 at a single center in Taiwan between April and June 2022. Demographic characteristics, comorbidities, vaccination status, and clinical outcomes were compared among different age groups (< 50 years, 50-74 years, and ≥ 75 years). Logistic regression analyses were performed to identify factors associated with critical illness and mortality. Results: The median age of the cohort was 72 years (interquartile range [IQR]: 58-82), and 59.6% were male. Older patients had a significantly higher prevalence of comorbidities. The overall rates of mortality and critical illness were 15.1% and 30.4%, respectively. There were no significant differences in the occurrence of critical illness among the age groups. However, mortality was significantly higher in patients aged ≥ 50 years. In the multivariate analysis, oral antiviral drug use (adjusted odds ratio [aOR]: 0.5, 95% CI [confidence interval]: 0.3-0.7) and being fully vaccinated (aOR: 0.6, 95% CI: 0.4-0.8) were associated with lower mortality, while having ≥ 3 risk factors (aOR: 1.9, 95% CI: 1.2-3.0) was associated with higher mortality. Additionally, age ≥ 50 years was associated with increased mortality; 50-74 years (aOR: 2.3, 95% CI: 1.1-4.8); ≥ 75 years (aOR: 2.3, 95% CI: 1.1-4.8) compared to age < 50 years. Similar factors were associated with critical illness. Conclusions: Older age was associated with higher mortality but not with an increased risk of critical illness in patients hospitalized with COVID-19. Oral antiviral drug use and being fully vaccinated were associated with better outcomes, highlighting the importance of early treatment and vaccination in mitigating severe COVID-19.
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