ArticleJournal of surgical case reports2026
Infusion of tPA-dornase for management of intraabdominal abscesses: a case report.
Article in Journal of surgical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Postoperative intra-abdominal abscesses are a common postsurgical complication and can lead to prolonged hospitalization and severe sepsis. The management of these abscesses is typically conservative, with intravenous antibiotics and percutaneous drainage. In those who fail conservative management, the next step is typically surgical intervention with washout. However, this may be contraindicated in a patient with multiple co-morbidities, who may not tolerate general anesthesia. Fibrinolysis via tissue plasminogen activator (tPA) and dornase infusion into the pleural cavity is well established for treatment of complicated empyemas. In comparison, infusion into the abdominal cavity has only been reported in one case series. In this case report, we describe our experience successfully treating an intraabdominal abscess with administration of tPA-dornase into the intra-abdominal cavity.
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