ArticleFrontiers in psychiatry2026
An exploratory study of altered regional homogeneity in Parkinson's disease with depression.
Article in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Depression is a prevalent non-motor symptom in Parkinson's disease (PD), yet its pathogenesis is unclear and biomarkers are lacking. This rs-fMRI study used Regional Homogeneity (ReHo) to explore neural correlates in PD with depression (DPD). Methods: We included 23 DPD, 24 non-depressed PD (NDPD), and 20 healthy controls (HC). ReHo analysis was applied to identify regional brain activity differences. Correlations between ReHo values and depression severity (HAMD scores) were examined. ROC analysis assessed the diagnostic utility of ReHo changes. Results: Compared to NDPD, DPD showed increased ReHo in the left inferior temporal gyrus (ITG) and decreased ReHo in the right middle frontal gyrus (MFG), left insula, and left hippocampus. ReHo in left ITG positively correlated with HAMD scores ( Conclusion: DPD is associated with distinct ReHo alterations. Abnormalities in the left ITG, right MFG, left insula, and left hippocampus may reflect the neural basis of DPD. Our exploratory analyses suggest that altered ReHo in the left insula and left hippocampus may hold potential as neuroimaging biomarkers.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.