ArticleAmerican journal of translational research2026
Effect of blood lipid on myocardial injury in rats with myocardial infarction.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
aimThis study investigated the effect of elevated blood lipid levels on myocardial injury in rats with myocardial infarction. MATERIALS AND
methodsSprague-Dawley (SD) rats were randomly assigned to six groups (n=9 per group): normal, sham, acute myocardial infarction (AMI), AMI+30% high-fat (HF), AMI+70% HF, AMI+100% HF and AMI+100% HF+PD (atorvastatin treatment). After 3 weeks of dietary intervention or treatment, serum and heart tissue samples were collected. Serum concentrations of triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB) and cardiac troponin I (cTnI) were measured. Myocardial pathologic changes were examined using H&E staining. Cardiomyocyte apoptosis was evaluated using the TUNEL assay, andcaspase-3 and caspase-12 protein expression levels in myocardial tissue were determined using western blot analysis.
resultsCompared to the normal group, TG, TC, LDL, LDH, CK-MB and cTnI levels were significantly increased, whereas HDL levels were significantly decreased in the AMI+30% HF, AMI+70% HF and AMI+100% HF groups. These changes were accompanied by a significant increase in cardiomyocyte apoptosis and marked pathological deterioration of myocardial tissue. By contrast, atorvastatin supplementation markedly improved lipid profiles and cardiac function and reduced cardiomyocyte apoptosis.
conclusionsAlterations in blood lipid levels are closely associated with cardiac dysfunction and myocardial injury following AMI
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