Evidence map›Paper›PMID 41868921›Full record

ArticleAmerican journal of translational research2026

Correlation of serum exosomal miR-21 with the risk of gastric cancer onset: its value for early diagnosis.

Changjiang Li, Chen Hong, Guosheng Zhou, Qianzi Chai, Jie Hu, Aihong Lv, Weiping Fang

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Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Changjiang LiDepartment of Gastroenterology, The First People's Hospital of Jiande Hangzhou 311600, Zhejiang, China.
Chen HongDepartment of Gastroenterology, The First People's Hospital of Jiande Hangzhou 311600, Zhejiang, China.
Guosheng ZhouDepartment of Gastroenterology, The First People's Hospital of Jiande Hangzhou 311600, Zhejiang, China.
Qianzi ChaiDepartment of Gastroenterology, The First People's Hospital of Jiande Hangzhou 311600, Zhejiang, China.
Jie HuDepartment of Gastroenterology, The First People's Hospital of Jiande Hangzhou 311600, Zhejiang, China.
Aihong LvDepartment of Gastroenterology, The First People's Hospital of Jiande Hangzhou 311600, Zhejiang, China.
Weiping FangDepartment of Gastroenterology, The First People's Hospital of Jiande Hangzhou 311600, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis research explored the connection between serum exosomal miR-21 expression and the risk of gastric cancer (GC), and evaluated the viability of using this non-invasive marker for early GC diagnosis.

methodsA retrospective evaluation was performed on 539 individuals who had received serum exosomal miR-21 testing. Based on diagnoses within 12 months, patients were categorized into a GC group (n=235) and a non-GC group (n=304). To measure the levels of exosomal miR-21, we used the technique of reverse transcription quantitative polymerase chain reaction (RT-qPCR).

resultsThe GC group had significantly higher body mass index (BMI), rates of manual labor, smoking, drinking, high-salt/pickled diet, chronic gastritis,

conclusionsSerum exosomal miR-21 is linked to GC and demonstrates potential as a non-invasive biomarker for early detection, particularly when combined with CA72-4.

Indexed as

correlationdiagnosisgastric cancerSerum exosomal miR-21

Identifiers

PMID41868921
PMCPMC13000797

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.