ArticleFrontiers in endocrinology2026
Age- and diet-dependent progression of retinal microvascular injury in GCK-MODY under metabolic stress.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Maturity-onset diabetes of the young type 2 (GCK-MODY), caused by heterozygous inactivating mutations in the glucokinase (GCK) gene, is generally considered a mild and stable form of diabetes with a relatively low risk of chronic complications. However, whether GCK deficiency predisposes to retinal microvascular injury under metabolic stress remains unclear. Methods: A GCK-Q26L knock-in mouse model (GCK Results: Under ND, retinal morphology and microvasculature were comparable between GCK Conclusions: This study demonstrates that GCK inactivation can predispose to retinal microvascular injury under prolonged metabolic stress. These findings support a NOX2-centered oxidative stress-linked inflammatory and apoptotic axis in late-stage retinal injury and highlight potential therapeutic targets for risk reappraisal in GCK-MODY.
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