ArticleFrontiers in immunology2026
Pregnancy-associated metabolic adaptations in circulating monocytes and macrophages favor clearance functions.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Immunology of pregnancy and sepsis: shared and specific pathways guiding future precision care.EBioMedicine · 2026Review
- Macrophage efferocytosis in pregnancy and pregnancy complications.Reproduction & fertility · 2026Review
- Fetal sex shapes maternal immune adaptation: placental extracellular vesicles differentially reprogram the phenotype, metabolism, and function of circulating monocytes.Frontiers in immunology · 2026Article
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Pregnancy requires coordinated immunometabolic adaptations that allow maternal immune tolerance while preserving tissue remodeling and host defense. Circulating monocytes contribute critically to these processes, yet how gestation shapes their metabolic state and functional specialization remains incompletely defined. Methods: We investigated the metabolic and functional phenotype of maternal monocytes during earlymid pregnancy (1620 weeks of gestation) and explored the contribution of trophoblast-derived signals using an Results: Maternal circulation was enriched in CD14 Discussion: Together, these findings identify a coordinated immunometabolic program in maternal monocytes integrating glycolysis, lactate signaling, and FAO, likely instructed by trophoblast-derived cues, to enhance efferocytic and pro-resolving functions during pregnancy. This metabolic adaptation may represent a systemic mechanism supporting immune tolerance and tissue remodeling in early gestation.
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Registered trials
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