ReviewFrontiers in immunology2026
Lactylation modification - a bridge between sepsis and macrophage metabolic reprogramming.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Lactylation: a metabolic-epigenetic driver in atherosclerosis pathogenesis and therapeutic targeting.Frontiers in cardiovascular medicine · 2026Review
- Lactylation: a novel epigenetic bridge connecting metabolic reprogramming and immune dysregulation in sepsis-associated ARDS.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is a life-threatening organ failure syndrome triggered by dysregulated host responses to infection. During disease progression, macrophages drive initial hyperinflammatory responses and critically regulate the subsequent immunosuppressive phase. Emerging evidence reveals that macrophage phenotypes dynamically adapt through metabolic reprogramming, creating phenotype-metabolism interdependence. Notably, lactate-long considered merely a glycolytic byproduct-now emerges as a key regulator through histone lactylation. This epigenetic modification fine-tunes macrophage functionality and corrects inflammatory imbalance in sepsis. This breakthrough illuminates lactylation's central role in macrophage regulation, opening new diagnostic and therapeutic avenues. This review comprehensively examines lactylation mechanisms and their impact on metabolic control in sepsis-associated macrophages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.