ReviewFrontiers in surgery2026
Research progress and prospects of exosomes from diverse cellular sources in the treatment of knee osteoarthritis: a narrative review.
Review in Frontiers in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Cryogel-based therapeutic platforms for disease modification in osteoarthritis.npj biomedical innovations · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Knee osteoarthritis (KOA) is a highly prevalent degenerative joint disease characterized by osteophyte formation at joint margins, subchondral bone sclerosis, and progressive degeneration of the articular cartilage. In advanced stages, it can result in severe functional impairment of the knee joint, imposing a substantial burden on patients' quality of life and on healthcare systems. Conventional intra-articular treatments, such as hyaluronic acid and corticosteroid injections, provide temporary pain relief but fail to achieve true tissue repair or regeneration. In recent years, several novel biological agents with regenerative potential have been introduced, yet their efficacy and safety remain debated. Exosomes, nanoscale vesicles secreted by cells, play essential roles in the pathophysiology of OA by mediating intercellular communication and regulating inflammatory and metabolic processes within the joint microenvironment. Exosomes derived from various cellular sources have been shown to promote chondrocyte proliferation and survival, suppress inflammation, maintain cartilage matrix homeostasis, and modulate subchondral bone remodeling and angiogenesis, demonstrating significant therapeutic promise for KOA. This review systematically summarizes current research on the mechanisms and therapeutic potential of exosomes derived from diverse cell types in KOA, highlighting recent advances and ongoing challenges. It aims to provide a theoretical foundation and reference framework for future basic studies and clinical translation of exosome-based therapies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.