ReviewInternational journal of nanomedicine2026
Nanoparticle-Enabled Photothermal Therapy Integrated with Gene Delivery, Immunotherapy, and Chemotherapy: A Comprehensive Review.
Review in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photothermal therapy (PTT) utilizes near-infrared (NIR)-responsive nanoparticles to induce controlled hyperthermia for tumor ablation and modulation of cellular and microenvironmental processes. Advances in nanomaterial engineering have enabled the integration of PTT with gene therapy, immunotherapy, and chemotherapy, wherein photothermal heating enhances membrane perturbation, accelerates endosomal escape, and initiates thermally triggered release of therapeutic payloads. This review summarizes the photothermal mechanisms of metallic, polymeric, hybrid, and semiconducting nanomaterials and examines how these platforms improve nucleic acid transport, immune activation, and chemotherapeutic performance. In addition, key translational challenges, including NIR penetration limits and thermotolerance, are briefly highlighted. By consolidating mechanistic insights and material-specific strategies, this review outlines current progress and future requirements for advancing clinically translatable PTT-based combination therapies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.