Evidence map›Paper›PMID 41869559›Full record

ArticleiScience2026

Panx1 deficiency exacerbates GAN diet-induced obesity by destabilizing β-catenin via GSK3β.

Hangfei Xu, Jinhan Zhao, Shan Lu, Qin Wang, Rui Sun, Yuxue Gao, Fang Xie, Yanjun Wang, Ryan Cao, Yingmei Feng and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Hangfei XuThe Third Unit of the Department of Hepatology, Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Jinhan ZhaoThe Third Unit of the Department of Hepatology, Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Shan LuThe Third Unit of the Department of Hepatology, Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Qin WangTianjin Key Lab of Radiation Medicine Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin 300192, China.
Rui SunThe Third Unit of the Department of Hepatology, Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Yuxue GaoThe Third Unit of the Department of Hepatology, Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Fang XieThe Third Unit of the Department of Hepatology, Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Yanjun WangThe Third Unit of the Department of Hepatology, Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Ryan CaoThe Third Unit of the Department of Hepatology, Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Yingmei FengThe Third Unit of the Department of Hepatology, Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Xiaoni LiuThe Third Unit of the Department of Hepatology, Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Buxin KouThe Third Unit of the Department of Hepatology, Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Mengyin ChaiThe Third Unit of the Department of Hepatology, Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Binghui LiThe Third Unit of the Department of Hepatology, Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Xiaoyu YuDepartment of Laboratory Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200123, China.
Jing ZhangThe Third Unit of the Department of Hepatology, Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Yang ZhangThe Third Unit of the Department of Hepatology, Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is a global health challenge and a major risk factor for metabolic diseases. Here, we show that Panx1-deficient mice develop severe obesity when fed a Gubra-Amylin (GAN) diet, characterized by adipocyte hypertrophy and disrupted lipid metabolism, while no such phenotype is observed on a conventional high-fat diet. Mechanistically, Panx1 deficiency leads to reduced non-phosphorylated β-catenin levels and its downstream targets, indicating impaired Wnt/β-catenin signaling. We further demonstrate that Panx1 interacts with β-catenin and GSK-3β, stabilizing β-catenin and preventing its degradation. Loss of Panx1 reduces β-catenin activity, impairs adipocyte hyperplasia, and promotes hypertrophic adipose expansion, thereby exacerbating obesity. These findings establish Panx1 as a key regulator of adipose tissue remodeling and suggest its potential as a tissue-specific target for obesity and related metabolic disorders.

Indexed as

Molecular biologyPhysiology

Identifiers

PMID41869559
PMCPMC12999355

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.