Evidence map›Paper›PMID 41869591›Full record

ArticleFrontiers in public health2026

Exposure to per- and poly-fluoroalkyl substances and associations with embryo quality and adverse pregnancy outcomes: a prospective cohort study.

Jiahui Wang, Zhe Li, Kuona Hu, Jingmei Hu, Ting Jiang, Jia Liao, Qian Zhang, Lijing Sun, Linlin Cui, Rong Chen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jiahui Wang *Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, China.
Zhe Li *Department of Urology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
Kuona Hu *State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.
Jingmei HuState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.
Ting JiangState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.
Jia LiaoState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.
Qian ZhangState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.
Lijing SunState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.
Linlin CuiState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.
Rong ChenDepartment of Gynecology and Obstetrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, China.
Tianxiang NiState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.
Wei ZhouState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Per- and poly-fluoroalkyl substances (PFASs) are a group of synthetized industrial pollutants which have been detected worldwide in both environment and humans and gradually raised public health concerns. Previous studies suggested that PFASs had reproductive toxicity and may do harm to pregnancy and children. However, it is still uncertain that whether effect of PFAS exposure on offsprings begins from embryo quality or post-implantation pregnancy outcomes. This study explores the association between exposure to PFASs and embryo quality or pregnancy outcomes to promote maternal-infant health. Methods: This study included 246 women who underwent their first Results: PFAS exposure had no significant association with high-quality blastocyst rate. Whereas, PFAS exposure had significantly adverse effect on miscarriage and live birth rate with the predominant risk of perfluoro-n-butanoic acid (PFBA) (For miscarriage, Q4 vs. Q1 OR: 6.44 (95%CI: 1.47, 33.72), Adjusted Conclusion: For women undergoing IVF/ICSI, exposure to PFASs was associated with higher miscarriage and lower live birth rate but had no adverse effect on embryo quality.

Indexed as

Environmental PollutantsFluorocarbonsMaternal ExposurePregnancy OutcomeAdultFemaleFertilization in VitroHumansPregnancyProspective StudiesSperm Injections, IntracytoplasmicEnvironmental PollutantsFluorocarbonsembryointracytoplasmic sperm injection (ICSI)in vitro fertilization (IVF)per- and poly-fluoroalkyl substances (PFAS)pregnancy

Identifiers

PMID41869591
PMCPMC13004126

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.