Case Report: Successful natural conception and delivery in a primary cancer survivor involving the reproductive, respiratory, and endocrine systems auth.

Background: Natural conception in patients with multiple primary neoplasms (MPNs) is exceedingly rare, particularly those involving metachronous triple cancers of the reproductive, respiratory, and endocrine systems. This article reports the case of a young female patient who suffered from three primary neoplasms successively covering the three major systems of the ovary, lung, and thyroid, and achieved successful natural conception and delivery through comprehensive management by a multi-disciplinary team (MDT). This case provides a valuable reference for the diagnosis and treatment of similar patients. Case Description: A 28-year-old married female underwent right ovary-preserving radical surgery for bilateral borderline serous ovarian tumors (Stage IIIB) in February 2021. She received six cycles of postoperative leuprorelin therapy. She was diagnosed with microinvasive adenocarcinoma of the left lung (Stage IA1, Conclusion: This is the first case of successful natural conception and delivery in a patient with metachronous MPNs involving the reproductive, respiratory, and endocrine systems. It establishes an MDT management pathway encompassing "determination of oncologic remission status, intervention for reversible fertility-compromising factors, and cross-trimester monitoring." This confirms that natural pregnancy is safe and feasible for patients in cancer remission, with multi-disciplinary collaboration and rigorous monitoring. The absence of postpartum neoplasm recurrence and abnormalities in offspring provides a practical paradigm for fertility management in patients with MPNs.