Evidence map›Paper›PMID 41869774›Full record

Trial reportAmerican journal of physiology. Endocrinology and metabolism2026

Acute metabolic effects of cannabinoid receptor modulators during sequential hyperglycemic, euglycemic-hyperinsulinemic clamps in healthy individuals.

Chee W Chia, Eric Y Tang, Roy G Cutler, Susan S You, Qinghua Chen, Adeline Y M Choo, Denise L Melvin, Christopher E Ramsden, Dimitrios Kapogiannis, Josephine M Egan

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in American journal of physiology. Endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chee W ChiaNational Institutes of Health, National Institute on Aging, Intramural Research Program, Baltimore, Maryland, United States.ORCID 0000-0003-3218-0141
Eric Y TangNational Institutes of Health, National Institute on Aging, Intramural Research Program, Baltimore, Maryland, United States.
Roy G CutlerNational Institutes of Health, National Institute on Aging, Intramural Research Program, Baltimore, Maryland, United States.ORCID 0000-0002-8961-3756
Susan S YouNational Institutes of Health, National Institute on Aging, Intramural Research Program, Baltimore, Maryland, United States.
Qinghua ChenNational Institutes of Health, National Institute on Aging, Intramural Research Program, Baltimore, Maryland, United States.
Adeline Y M ChooNational Institutes of Health, National Institute on Aging, Intramural Research Program, Baltimore, Maryland, United States.ORCID 0009-0000-9405-092X
Denise L MelvinNational Institutes of Health, National Institute on Aging, Intramural Research Program, Baltimore, Maryland, United States.ORCID 0009-0002-6102-6207
Christopher E RamsdenNational Institutes of Health, National Institute on Aging, Intramural Research Program, Baltimore, Maryland, United States.
Dimitrios KapogiannisNational Institutes of Health, National Institute on Aging, Intramural Research Program, Baltimore, Maryland, United States.
Josephine M EganNational Institutes of Health, National Institute on Aging, Intramural Research Program, Baltimore, Maryland, United States.ORCID 0000-0002-8945-0053

Funding

The endogenous cannabinoid system and glucose homeostasisZIAAG000960 · NIA · NATIONAL INSTITUTE ON AGING · PI CHIA, CHEE W · 2009 to 2025
$4.1M
HHS | NIH | National Institute on Aging (NIA) Intramural Research ProgramIntramural NIH HHS ZIA AG000960
6 · The paper itself

Abstract

The endocannabinoid (eCB) system is involved in a vast array of physiological processes including regulating metabolism through insulin secretion and action. In this physiological study of 21 healthy men, we investigated the acute effects of a nonspecific cannabinoid receptor agonist nabilone (NAB 2 mg) and a specific cannabinoid receptor 1 (CB

Indexed as

Cannabinoid Receptor ModulatorsDronabinolHyperglycemiaHyperinsulinismAdultArachidonic AcidsBlood GlucoseCannabinoid Receptor AgonistsCannabinoid Receptor AntagonistsEndocannabinoidsGlucose Clamp TechniqueHumansInsulinInsulin ResistanceInsulin SecretionMaleanandamideArachidonic AcidsBlood GlucoseCannabinoid Receptor AgonistsCannabinoid Receptor AntagonistsCannabinoid Receptor ModulatorsDronabinolEndocannabinoidsInsulinPolyunsaturated AlkamidesReceptor, Cannabinoid, CB1cannabinoid receptorsclampendocannabinoidsglucose metabolismN-acylethanolamines

Identifiers

PMID41869774
PMCPMC13113679

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.