ArticleJournal of cellular and molecular medicine2026
An Integrated Evaluation Framework for Adult Heart Regeneration.
Article in Journal of cellular and molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
Abstract
Myocardial infarction (MI) remains a primary global cause of mortality due to irreversible cardiomyocyte loss. While promoting endogenous regeneration offers a highly promising therapy, its validation is critically hindered by the lack of standardised, comprehensive methodologies for quantitative assessment. To address this, we developed an integrated, systematically validated experimental framework for the precise evaluation of heart regeneration after ischemic injury in adult mice. This framework standardises four key assessment dimensions: (1) serial echocardiography mapping for precise serial evaluation of left ventricular function and structural changes; (2) standardised Masson's trichrome staining with systematic transverse sampling across five sections for reproducible quantification of post-ischemic scar burden; (3) stringent multi-marker strategy (EdU, pH 3 and Aurora B) for the accurate quantification of cardiomyocyte cell-cycle reactivation; (4) total cardiomyocyte enumeration achieved by employing enzymatic digestion to derive definitive quantitative metrics, confirming successful cell replenishment. This integrated framework establishes detailed and reproducible methodological standards to significantly enhance the accuracy and reliability of heart regeneration research. It thereby provides a robust reference for the standardised assessment of heart regeneration in adult mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.