Evidence map›Paper›PMID 41869877›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat.

Duo Su, Haosen Yang, Xiaokai Li, Tingting Jiang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Yan Wang, Li Li, Hongping Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Duo SuKey Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.
Haosen YangKey Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.
Xiaokai LiChongqing Academy of Animal Sciences, Chongqing, P. R. China.
Tingting JiangKey Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.
Siyuan ZhanKey Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.
Tao ZhongKey Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.
Jiazhong GuoKey Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.
Yan WangKey Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.
Li LiKey Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.
Hongping ZhangKey Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.
Linjie WangKey Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China.ORCID https://orcid.org/0000-0001-9672-7703

Funding

National Natural Science Foundation of China 32472852Science and Technology Projects of XizangAutonomous Region XZ202401ZY0083
6 · The paper itself

Abstract

Brown adipose tissue (BAT) undergoes progressive age-related involution into white adipose tissue (WAT), yet the epigenetic mechanisms underlying BAT whitening remain unclear. This study investigates the transcriptomic dynamics of goat perirenal adipose tissue (PRAT) across four postnatal stages and profiles active histone modifications and chromatin accessibility in PRAT at postnatal day 1 (BAT) and day 90 (WAT). PRAT whitening coincides with reduced enrichment of active histone marks and decreased chromatin accessibility at genes involved in thermogenesis and mitochondrial function, critical for maintaining brown adipocyte identity. Integration of high-resolution PGC1A chromatin interaction mapping identifies two BAT-specific active enhancers, PGC1A-En1 and PGC1A-En2, which exhibit additive effects and are further activated under cold stimulation. Functional repression of PGC1A-En1 and/or PGC1A-En2 in goat brown adipocytes reduces PGC1A expression and impairs thermogenic capacity, highlighting the pivotal role of PGC1A-En1. Consistently, lentivirus-mediated repression of the conserved mouse Pgc1a-En1 in vivo decreases Pgc1a expression and attenuates cold-induced thermogenesis in BAT. Notably, the conserved PGC1A-hEn1 also functions as a critical regulatory element required for PGC1A expression and thermogenic activation in human brown adipocytes. These findings elucidate epigenetic mechanisms controlling BAT activity and identify conserved enhancer elements as potential therapeutic targets for metabolic disorders.

Indexed as

Adipose Tissue, BrownEnhancer Elements, GeneticPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaThermogenesisAdipocytes, BrownAdipose Tissue, WhiteAnimalsGoatsMicePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphabrown adipose tissueconserved enhancerepigenomicsPGC1A transcription regulationthermogenesis

Identifiers

PMID41869877
PMCPMC13588000

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.