Evidence map›Paper›PMID 41869887›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Identifying Cytokine Motif-Containing, Immunomodulatory Bacterial Proteins in Human Gut Microbiome.

Ziyu Wang, Siqi Guo, Jing Li, Qianqian Huang, Jing Ning, Binbin Xia, Xun Lv, Xiang Liu, Zeyu Gao, Jine Li and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ziyu WangLaboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0000-0002-8615-1816
Siqi GuoLaboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0009-0004-2318-6845
Jing LiBeijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-6385-8958
Qianqian HuangLaboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0009-0005-5702-0744
Jing NingBeijing Key Laboratory for Helicobacter Pylori Infection and Upper Gastrointestinal Diseases (BZ0371), Department of Gastroenterology, Peking University Third Hospital, Beijing, China.
Binbin XiaLaboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0000-0002-1174-5273
Xun LvLaboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0000-0003-0261-800X
Xiang LiuLaboratory of Microbial Resources and Biotechnology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0000-0002-9372-9110
Zeyu GaoState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0009-0004-5050-5258
Jine LiUniversity of Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0000-0003-0094-9024
Longchao LiuLaboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0000-0003-3394-5919
Moshi SongUniversity of Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0000-0001-9929-8975
Jun WangLaboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0000-0002-8859-7707

Funding

National Key Research and Development Program of China 2025YFA1309200Open funding project of State Key Laboratory of Pharmaceutical preparation 2023KF-05
6 · The paper itself

Abstract

Accumulating evidence emphasizes the importance of microbiota-immune interactions in health and disease development, and identified bacteria-derived small-molecule metabolites as well as macromolecules such as peptides and proteins as promising therapeutic approaches. Here, we identify cytokine motif-containing, immunomodulatory bacterial proteins (CMCPs) as a special category of bacterial proteins in both bacterial genomes and gut metagenomes using Hidden Markov Models (HMMs). We further find eight colorectal cancer‑associated CMCPs differentially enriched in patients or healthy controls. Engineered E. coli Nissle 1917 (EcN) expressing selected CMCPs administered to Apc

Indexed as

Bacterial ProteinsColorectal NeoplasmsCytokinesGastrointestinal MicrobiomeImmunologic FactorsAnimalsEscherichia coliHumansMiceBacterial ProteinsCytokinesImmunologic Factorscolorectal cancercytokine motif‐containing proteinsengineered bacteriagut microbiotametagenome

Identifiers

PMID41869887
PMCPMC13205780

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.