Evidence map›Paper›PMID 41870543›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Dapagliflozin attenuates myocardial fibrosis after myocardial infarction through regulating Lnc-Ang362/miR-200b-3p.

Xueqian Huang, Jialin Lu, Ziling Huang, Yixin Wang, Xuelin Wang, Junqing Yang, Moussa Ide Nasser, Xuyu He

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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xueqian HuangDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Southern Medical University, Guangzhou, China.
Jialin LuGuangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, China.
Ziling HuangDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Southern Medical University, Guangzhou, China.
Yixin WangDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Southern Medical University, Guangzhou, China.
Xuelin WangDepartment of Cardiology, the Affiliated Huizhou Hospital, Guangzhou Medical University, Guangzhou, Guangdong Province, China.
Junqing YangDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Southern Medical University, Guangzhou, China. yangjunqing@gdph.org.cn.
Moussa Ide NasserDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Southern Medical University, Guangzhou, China. moussa@gdph.org.cn.
Xuyu HeDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Southern Medical University, Guangzhou, China. hexuyu@gdph.org.cn.

Funding

Li Xin Traditional Chinese Medicine Research and Innovation Fund 2023-CCA-TCM-033Natural Science Foundation of Guangdong Province 2024A1515011451
6 · The paper itself

Abstract

Sodium-Glucose Cotransporter 2 inhibitor (SGLT2i) is cardioprotective in cardiovascular events regardless of diabetes, but the mechanism remains limited. Here, we evaluated the effect of dapagliflozin (DAPA) in myocardial remodeling after myocardial infarction (MI). In this study, 64 Sprague-Dawley rats were randomized into control, sham, MI, and MI + DAPA groups (n = 8 in each group) and had a 4-week treatment. Then the hearts were obtained for further exploration, and primary cardiac fibroblasts (CFs) were induced by transforming growth factor (TGF)-β

Indexed as

Benzhydryl CompoundsGlucosidesMicroRNAsMyocardial InfarctionMyocardiumRNA, Long NoncodingSodium-Glucose Transporter 2 InhibitorsAnimalsApoptosisCells, CulturedFibroblastsFibrosisMaleRatsRats, Sprague-DawleyTransforming Growth Factor beta1Benzhydryl CompoundsdapagliflozinGlucosidesMicroRNAsMIRN200 microRNA, ratRNA, Long NoncodingSodium-Glucose Transporter 2 InhibitorsTransforming Growth Factor beta1DAPAlnc-Ang362MiR-200b-3pMyocardial fibrosisSGLT2i

Identifiers

PMID41870543

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.