ReviewOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2026
Does osteosarcopenia synergistically increase risk for incident falls and fractures? A systematic review and meta-analysis.
Review in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
It is unclear whether comorbid low bone mineral density (BMD) and sarcopenia, known as 'osteosarcopenia', synergistically increase fall and fracture risk. This review aims to determine whether osteosarcopenia confers a greater risk for incident falls and fractures than low BMD or sarcopenia alone. Relevant databases were searched from inception to 2025 for prospective studies in populations aged ≥ 50 years comparing fall and fracture risk in osteosarcopenia to low BMD (T-Score < -1.0) or sarcopenia alone. Meta-analyses calculated risk ratios (RR) and measures of interaction on additive (relative excess risk due to interaction; RERI) and multiplicative (multiplicative interaction ratio; MR) scales. Seven records (n = 813) were included. Osteosarcopenia was associated with similar fracture risk as low BMD (RR 1.22; 95% CI 0.96, 1.56; k = 6, I
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