Trial reportEuropean journal of pediatrics2026
Conservative versus conventional oxygenation target in children admitted in PICU: a randomized controlled trial.
Trial report in European journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study is to compare conservative versus conventional oxygen saturation targets on clinical outcomes in critically ill children requiring respiratory support. This open label randomized controlled trial was conducted in a tertiary care pediatric intensive care unit between May 2023 and November 2024. Children aged 1 month to 15 years requiring invasive or noninvasive oxygen therapy were randomized to conservative (SpO₂ 88-92%) or conventional (SpO₂ 94-99%) oxygen saturation targets. Fraction of inspired oxygen was titrated to maintain assigned targets. The primary outcome was a composite of death and organ support at 30 days. Secondary outcomes included mortality at 7 and 30 days, duration of respiratory support and oxygen therapy, length of PICU and hospital stay, and oxidative stress assessed by serum malondialdehyde (MDA) at baseline and day 7. A total of 178 children were randomized. Baseline characteristics and illness severity were comparable between groups. The median composite outcome score was 8 (IQR 4-20.25) in the conservative group and 10 (IQR 5-20) in the conventional group (p = 0.15). Duration of respiratory support (4 vs 6 days; p = 0.003) and oxygen therapy (8 vs 100 h; p < 0.001) were significantly lower in the conservative group. Mortality at 7 and 30 days, organ support days, length of stay, and MDA levels were similar.Conclusion: Conservative oxygen saturation targets (88-92%) were safe and resulted in similar mortality and organ dysfunction compared with conventional targets, with reduced duration of respiratory support and oxygen therapy. Larger multicenter trials are needed to confirm these findings.Trial registration: The trial is registered in Clinical Trial Registry India (CTRI) (registration number CTRI/2023/11/060105, date of registration 21/11/2023.
Indexed as
Identifiers
41870740What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.