Evidence map›Paper›PMID 41872174›Full record

ArticleNature communications2026

Antigen-specific immunotherapy with a CD4

James E DiLisio, K Scott Beard, Tobias Neef, Stephen D Miller, Janet M Wenzlau, Maki Nakayama, Marc A D'Antonio, Braxton L Jamison, Kelli S Nicholson, Rocky L Baker and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

James E DiLisioDepartment of Immunology and Microbiology, School of Medicine, University of Colorado, Aurora, CO, USA. james.dilisio@cuanschutz.edu.ORCID http://orcid.org/0000-0001-9216-0375
K Scott BeardBarbara Davis Center for Childhood Diabetes, Aurora, CO, USA.
Tobias NeefDepartment of Microbiology-Immunology, School of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Stephen D MillerDepartment of Microbiology-Immunology, School of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-9556-0718
Janet M WenzlauDepartment of Immunology and Microbiology, School of Medicine, University of Colorado, Aurora, CO, USA.
Maki NakayamaDepartment of Immunology and Microbiology, School of Medicine, University of Colorado, Aurora, CO, USA.
Marc A D'AntonioDepartment of Immunology and Microbiology, School of Medicine, University of Colorado, Aurora, CO, USA.
Braxton L JamisonAllen Institute for Immunology, Seattle, WA, USA.
Kelli S NicholsonDepartment of Immunology and Microbiology, School of Medicine, University of Colorado, Aurora, CO, USA.
Rocky L BakerDepartment of Immunology and Microbiology, School of Medicine, University of Colorado, Aurora, CO, USA.ORCID http://orcid.org/0000-0001-8361-8655
Tonya M BrunettiDepartment of Immunology and Microbiology, School of Medicine, University of Colorado, Aurora, CO, USA.
Laurent GapinDepartment of Immunology and Microbiology, School of Medicine, University of Colorado, Aurora, CO, USA.ORCID http://orcid.org/0000-0001-9730-5174
Kathryn HaskinsDepartment of Immunology and Microbiology, School of Medicine, University of Colorado, Aurora, CO, USA. katie.haskins@cuanschutz.edu.ORCID http://orcid.org/0000-0002-5430-6254

Funding

NIDDK NIH HHS F31 DK113693U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) F31-AI181452U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01-DK081166
6 · The paper itself

Abstract

Pancreatic islet transplantation offers a potential cure for autoimmune type 1 diabetes (T1D) but requires immunosuppression to prevent recurrent, T cell-mediated autoimmunity. Antigen-specific immunotherapy is a targeted alternative that induces peripheral tolerance in autoreactive T cells without broad immunosuppression. Tolerance induction with antigen-specific therapies may induce dominant tolerance, extending to T cell clones other than those targeted by the therapy. However, the mechanism of this suppression remains unclear. Using pancreatic islet transplantation in NOD mice, we show that induction of tolerance to a CD4

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDiabetes Mellitus, Type 1ImmunotherapyIslets of Langerhans TransplantationAnimalsCell DifferentiationFemaleGraft SurvivalInsulinInterleukin-10Islets of LangerhansMiceMice, Inbred NODInsulinInterleukin-10

Identifiers

PMID41872174
PMCPMC13171880

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.