Evidence map›Paper›PMID 41872193›Full record

ArticleNature communications2026

Asymmetric histone inheritance regulates olfactory stem cell fates during regeneration.

Binbin Ma, Guanghui Yang, Jonathan Yao, Charles Wu, Jean Pinckney Vega, Gabriel Manske, Saher Sue Hammoud, Satrajit Sinha, Abhyudai Singh, Haiqing Zhao and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Binbin MaHoward Hughes Medical Institute, Department of Biology, Johns Hopkins University, Baltimore, MD, USA.
Guanghui YangHoward Hughes Medical Institute, Department of Biology, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-2784-521X
Jonathan YaoDepartment of Biology, Johns Hopkins University, Baltimore, MD, USA.
Charles WuDepartment of Biology, Johns Hopkins University, Baltimore, MD, USA.
Jean Pinckney VegaDepartment of Biology, Johns Hopkins University, Baltimore, MD, USA.
Gabriel ManskeCellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI, USA.
Saher Sue HammoudDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-5040-6370
Satrajit SinhaDepartment of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, SUNY at Buffalo, Buffalo, NY, USA.ORCID http://orcid.org/0000-0002-9574-4576
Abhyudai SinghElectrical & Computer Engineering, University of Delaware, Newark, DE, USA.ORCID http://orcid.org/0000-0002-1451-2838
Haiqing ZhaoDepartment of Biology, Johns Hopkins University, Baltimore, MD, USA. hzhao@jhu.edu.ORCID http://orcid.org/0000-0003-4275-9843
Xin ChenHoward Hughes Medical Institute, Department of Biology, Johns Hopkins University, Baltimore, MD, USA. xchen32@jhu.edu.ORCID http://orcid.org/0000-0002-6990-0926

Funding

The Role of CFAP69 in OlfactionR01DC016065 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI ZHAO, HAIQING · 2018 to 2022
$2.0M
Generalized fluctuation test for deciphering phenotypic switching within cell populationsR35GM148351 · NIGMS · UNIVERSITY OF DELAWARE · PI Abhyudai Singh · 2023 to 2026
$1.6M
NIDCD NIH HHS R01 DC016065NIGMS NIH HHS R35 GM148351
6 · The paper itself

Abstract

The olfactory epithelium possesses an adult stem cell population, the horizontal basal cells (HBCs), to permit lifelong tissue regeneration. Here, we show that HBCs exhibit asymmetric inheritance of histone H4 but not H2A-H2B during olfactory epithelium regeneration in mice. Primary HBC cultures further revealed asymmetric histone inheritance for H3 and H3.3. Upon mitotic exit, asymmetric histone inheritance correlates with asynchronous transcription re-initiation and differential enrichment of p63, a key transcription factor for HBC cell fate. Disruption of asymmetric histone inheritance abolishes these asymmetric cellular features and attenuates olfactory epithelium regeneration and smell behavior recovery. Single-cell RNA sequencing of paired HBC daughters in culture further supports asymmetric multilineage cell fate priming. Together, these findings reveal asymmetric histone inheritance in a mammalian adult stem cell lineage and highlight its biological significance in neural tissue regeneration and animal behavior.

Indexed as

Adult Stem CellsHistonesOlfactory MucosaRegenerationAnimalsCell DifferentiationCell LineageFemaleMiceMice, Inbred C57BLTrans-ActivatorsHistonesTrans-ActivatorsTrp63 protein, mouse

Identifiers

PMID41872193
PMCPMC13172531

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.