Uncoupling memory impairments from autism-associated behaviors in Chd2 deficient mice.

Abstract read

In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sang Ho YoonDepartment of Anatomy & Neurobiology, University of California, Irvine, CA, 92617, USA.ORCID http://orcid.org/0000-0003-2771-1593

Robert F HuntDepartment of Anatomy & Neurobiology, University of California, Irvine, CA, 92617, USA. robert.hunt@uci.edu.ORCID http://orcid.org/0000-0003-4490-8718

Funding

Bidirectional control of Chd2 haploinsufficiencyR01NS126399 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Robert F Hunt · 2023 to 2026

$2.1M

NINDS NIH HHS R01 NS126399U.S. Department of Health & Human Services | National Institutes of Health (NIH) NS126399

6 · The paper itself

Abstract

Mutations in the chromatin remodeler, CHD2, are strongly associated with moderate to severe intellectual disability, autism and epilepsy, but the direct contribution of CHD2 mutations to clinical phenotypes is poorly understood. We report developmental and sex-specific behavioral changes in mice carrying a heterozygous mutation in Chd2. Notably, Chd2 mutants display a range of abnormal behaviors including impairments in multiple forms of memory and social interaction. Memory impairments and memory-relevant transcriptional changes observed in Chd2

Indexed as

Autistic DisorderDNA-Binding ProteinsMemory DisordersAnimalsBehavior, AnimalBrainDisease Models, AnimalFemaleInterneuronsMaleMemoryMiceMice, Inbred C57BLMice, KnockoutMutationSocial BehaviorChd2 protein, mouseDNA-Binding Proteins

Identifiers

PMID41872520

DOI10.1038/s41380-026-03539-x

PMCPMC13364646

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.