Evidence map›Paper›PMID 41872989›Full record

ArticleHuman brain mapping2026

Testing for Network Specificity in Brain-Behavior Associations Using Ordinal Dominance Curves.

Noah Hillman, Sarah M Weinstein, Joëlle Bagautdinova, Kevin Y Sun, Matthew Cieslak, Taylor Salo, Yong Fan, Arielle S Keller, Aaron F Alexander-Bloch, Simon N Vandekar and 4 more

Abstract read
In one paragraph

Article in Human brain mapping, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Noah HillmanPenn Statistics in Imaging and Visualization Endeavor, Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Sarah M WeinsteinDepartment of Epidemiology and Biostatistics, Temple University College of Public Health, Philadelphia, Pennsylvania, USA.
Joëlle BagautdinovaPenn Lifespan Informatics and Neuroimaging Center, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Kevin Y SunPenn Lifespan Informatics and Neuroimaging Center, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-3230-4319
Matthew CieslakPenn Lifespan Informatics and Neuroimaging Center, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-1931-4734
Taylor SaloPenn Lifespan Informatics and Neuroimaging Center, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Yong FanCenter for AI and Data Science for Integrated Diagnostics (AI2D), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Arielle S KellerDepartment of Psychological Sciences, University of Connecticut, Storrs, Connecticut, USA.
Aaron F Alexander-BlochPenn Lifespan Informatics and Neuroimaging Center, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Simon N VandekarDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Armin RaznahanSection on Developmental Neurogenomics, National Institute of Mental Health Intramural Research Program, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0002-5622-1190
Theodore D SatterthwaitePenn Lifespan Informatics and Neuroimaging Center, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Haochang ShouPenn Statistics in Imaging and Visualization Endeavor, Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Russell T ShinoharaPenn Statistics in Imaging and Visualization Endeavor, Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Funding

Longitudinal Mapping of Network Development Underlying Executive Dysfunction in AdolescenceR01MH113550 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Danielle Smith Bassett, Theodore Satterthwaite · 2018 to 2026
$6.9M
Personalized Functional Network Modeling to Characterize and Predict Psychopathology in YouthR01EB022573 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Yong Fan, Theodore Satterthwaite · 2016 to 2026
$6.0M
Inter-modal Coupling Image AnalyticsR01MH112847 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Theodore Satterthwaite, Russell Takeshi Shinohara · 2017 to 2026
$5.9M
Precision mapping of individualized executive networks in youthR37MH125829 · NIMH · UNIVERSITY OF MINNESOTA · PI Damien A Fair, Theodore Satterthwaite · 2021 to 2026
$4.7M
The Genetics of Personalized Functional MRI NetworksR01MH132934 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI Aaron Felix Alexander-Bloch · 2023 to 2026
$4.2M
Harmonization of Multi-Site Neuroimaging Data from Complex Study DesignsR01MH123550 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI SHINOHARA, RUSSELL TAKESHI · 2020 to 2025
$4.0M
The Neuroimaging Brain Chart Software SuiteU24NS130411 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Christos Davatzikos, Yong Fan · 2023 to 2026
$3.7M
Fast and robust deep learning tools for analysis of neuroimaging data of Alzheimer's diseaseR01AG066650 · NIA · UNIVERSITY OF PENNSYLVANIA · PI FAN, YONG · 2021 to 2025
$3.4M
Precision brain charts for imaging-genomics of schizophrenia and the psychosis spectrumR01MH133843 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI Aaron Felix Alexander-Bloch · 2023 to 2026
$3.2M
Advanced Statistical Analytics of MRI in MSR01NS112274 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SHINOHARA, RUSSELL TAKESHI · 2020 to 2024
$2.8M
Radiomics for Clinically-Acquired Brain MRIs of Youth with Neurodevelopmental DisordersR01MH134896 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI Aaron Felix Alexander-Bloch · 2024 to 2026
$2.3M
Semiparametric Inference for Psychiatric NeuroimagingR01MH123563 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI VANDEKAR, SIMON NEIL · 2020 to 2024
$2.1M
Brain and Behavior Research Foundation, NARSAD Young Investigator AwardNIA NIH HHS R01AG066650NIBIB NIH HHS R01EB022573NIMH NIH HHS 1L30MH131061-01NIMH NIH HHS 1ZIAMH002949NIMH NIH HHS R01MH112847NIMH NIH HHS R01MH113550NIMH NIH HHS R01MH123550NIMH NIH HHS R01MH123563NIMH NIH HHS R01MH132934NIMH NIH HHS R01MH133843NIMH NIH HHS R01MH134896NIMH NIH HHS R37MH125829NINDS NIH HHS R01NS112274NINDS NIH HHS U24NS130411
6 · The paper itself

Abstract

Interpreting brain-behavior relationships through the lens of anatomical parcellations or functional networks is commonplace in human brain mapping. However, statistical approaches for testing whether brain-behavior associations are stronger (i.e., enriched) within a region of interest remain underdeveloped. Here, we propose a permutation-based approach for network enrichment testing using ordinal dominance curves (NETDOM). In simulation studies, we demonstrate that NETDOM properly controls the type I error rate-unlike other prominent enrichment methods-while exhibiting increased statistical power when enrichment occurs in a subset of in-network locations. Using data from two large-scale neurodevelopmental cohorts, we illustrate that NETDOM effectively detects enriched associations between structural and functional brain measures and neurocognitive performance.

Indexed as

BrainBrain MappingNerve NetComputer SimulationHumansMagnetic Resonance ImagingNeural Pathwaysbrain‐behavior associationsbrain networksbrain‐wide association studiesenrichmenthypothesis testingintersection–union testingordinal dominance curves

Identifiers

PMID41872989
PMCPMC13081700

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.