Evidence map›Paper›PMID 41873114›Full record

ReviewMicrobial biotechnology2026

Relationship Between Gut Microbiota and Cancer Neuro-Immunity.

Danyang Wang, Ruirui Cui, Chang You, Wanlin Zheng, Luyao Wang, Yingqi Yang, Hongkai Yu, Bota Cui

Abstract readReview
In one paragraph

Review in Microbial biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Danyang WangThe Second School of Clinical Medicine, Nanjing Medical University, Nanjing, China.
Ruirui CuiSchool of Rehabilitation Medicine, Nanjing Medical University, Nanjing, China.
Chang YouSchool of Stomatology, Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0009-0009-4676-7905
Wanlin ZhengSchool of Public Health, Nanjing Medical University, Nanjing, China.
Luyao WangThe Second School of Clinical Medicine, Nanjing Medical University, Nanjing, China.
Yingqi YangThe Second School of Clinical Medicine, Nanjing Medical University, Nanjing, China.
Hongkai YuThe Second School of Clinical Medicine, Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0009-0002-8938-8939
Bota CuiDepartment of Microbiota Medicine & Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0002-5952-8227

Funding

Medical research key project of Jiangsu Commission of Health K2023011
6 · The paper itself

Abstract

The nervous system and the immune system are integral components of the tumour microenvironment, and neuroimmune mechanisms play critical roles in tumour metastasis, immune evasion and metabolic reprogramming. However, the relationship between the gut microbiota and cancer neuro-immunity remains poorly understood. This knowledge gap hampers our understanding of how these systems contribute to tumour progression and therapeutic resistance. This article systematically explores the interactions among the gut microbiota, the nervous system and the immune system in the regulation of tumour progression, with a particular focus on elucidating the pathways by which the gut microbiota and its metabolites modulate tumour phenotypes via neuroimmune mechanisms, and summarises the regulatory mechanisms through which cancer neuro-immunity shapes gut microbiota composition. Additionally, this article summarises the interplay between immunotherapy and cancer neuro-immunity, and explores the potential of microbiota-based interventions, such as faecal microbiota transplantation, probiotics, prebiotics and synbiotics, to enhance the efficacy of immunotherapy through neuroimmune mechanisms.

Indexed as

Gastrointestinal MicrobiomeNeoplasmsNeuroimmunomodulationAnimalsFecal Microbiota TransplantationHumansImmunotherapyPrebioticsProbioticsTumor MicroenvironmentPrebioticsgut microbiotaimmunotherapyneuroimmunitytumour microenvironment

Identifiers

PMID41873114
PMCPMC13097368

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.