ArticleCureus2026
Short-Term Efficacy and Safety of Hemodialysis Using Super High-Flux Dialyzers Compared With Online Hemodiafiltration: An Exploratory Cross-Sectional Study in Vietnam.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Background Online hemodiafiltration (OL-HDF) improves middle-molecule clearance but requires ultrapure water systems and specialized infrastructure, limiting implementation in many low- and middle-income countries. Super high-flux (SHF) dialyzers may enhance middle-molecule removal using standard hemodialysis platforms. This exploratory, single-session study evaluated the short-term biochemical efficacy and safety of SHF hemodialysis (SHF-HD) compared with post-dilution OL-HDF in a Vietnamese tertiary center. Methods In this cross-sectional pilot study, 30 maintenance hemodialysis patients (15 SHF-HD; 15 OL-HDF) were evaluated during a single 240-minute session. Pre- and post-dialysis concentrations of urea, β₂-microglobulin, parathyroid hormone, interleukin-6, leptin, albumin, and C-reactive protein (CRP) were measured. Reduction ratios were hematocrit-corrected. This study was not powered for non-inferiority or equivalence testing. Results Baseline characteristics were comparable, although blood flow rate (Qb) was higher in the OL-HDF group (270 ± 22 vs. 240 ± 24 mL/min; p = 0.008). No statistically significant differences were detected in reduction ratios of β₂-microglobulin (65.05% vs. 68.20%, p = 0.561), parathyroid hormone (66.32% vs. 63.57%, p = 0.803), interleukin-6 (23.62% vs. 21.20%, p = 0.213), or leptin (41.08% vs. 36.36%, p = 0.678). Serum albumin changes were minimal in both groups (-0.40 ± 0.68 vs. -0.44 ± 1.32 g/L, p = 0.911), and CRP remained stable. No intradialytic adverse events occurred. Conclusions In this exploratory Vietnamese pilot study, SHF-HD demonstrated similar short-term biochemical performance to OL-HDF during a single dialysis session, without acute safety concerns. Given the small sample size, non-randomized allocation, moderate convective volume, and absence of direct albumin quantification, these findings should be interpreted cautiously. Larger, prospective studies are required to determine long-term clinical implications.
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