Evidence map›Paper›PMID 41873455›Full record

ArticleACS chemical biology2026

Photocaged Chloroquine Derivatives for the Light-Dependent Inhibition of Autophagy in Cancer Stem Cells.

Sofía Alonso-Manresa, Carme Serra, Lourdes Muñoz, Marina Bataller, Yoelsis Garcia-Mayea, Matilde Esther Lleonart, Belen Garcia Prats, Sandra Mancilla Zamora, Zamira Vanessa Diaz Riascos, Amadeu Llebaria and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sofía Alonso-ManresaMCS, Laboratory of Medicinal Chemistry and Synthesis, Department of Biological Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain.
Carme SerraMCS, Laboratory of Medicinal Chemistry and Synthesis, Department of Biological Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain.
Lourdes MuñozMCS, Laboratory of Medicinal Chemistry and Synthesis, Department of Biological Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain.
Marina BatallerHead and neck cancer: Biomedical Research in Tumor Stem Cells Group, Vall d'Hebron Research Institute (VHIR), 08035 Barcelona, Spain.
Yoelsis Garcia-MayeaHead and neck cancer: Biomedical Research in Tumor Stem Cells Group, Vall d'Hebron Research Institute (VHIR), 08035 Barcelona, Spain.
Matilde Esther LleonartHead and neck cancer: Biomedical Research in Tumor Stem Cells Group, Vall d'Hebron Research Institute (VHIR), 08035 Barcelona, Spain.
Belen Garcia PratsClinical Biochemistry, Drug Delivery and Therapy Group (CB-DDT), Vall d'Hebron Institute of Research (VHIR), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Passeig de la Vall d'Hebron, 119-129, 08035 Barcelona, Spain.
Sandra Mancilla ZamoraClinical Biochemistry, Drug Delivery and Therapy Group (CB-DDT), Vall d'Hebron Institute of Research (VHIR), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Passeig de la Vall d'Hebron, 119-129, 08035 Barcelona, Spain.
Zamira Vanessa Diaz RiascosClinical Biochemistry, Drug Delivery and Therapy Group (CB-DDT), Vall d'Hebron Institute of Research (VHIR), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Passeig de la Vall d'Hebron, 119-129, 08035 Barcelona, Spain.
Amadeu LlebariaMCS, Laboratory of Medicinal Chemistry and Synthesis, Department of Biological Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain.
Laia Josa-CulleréMCS, Laboratory of Medicinal Chemistry and Synthesis, Department of Biological Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Jordi Girona 18-26, 08034 Barcelona, Spain.ORCID 0000-0002-3275-9025

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chloroquine (CQ) and hydroxychloroquine (HCQ) inhibit autophagy and have shown promise as adjuvant anticancer agents, particularly for targeting therapy-resistant cancer stem cells (CSCs). However, their clinical utility is limited by systemic toxicity and poor tumor selectivity. Here, we report the design, synthesis, and photochemical evaluation of [7-(diethylamino)coumarin-4-yl]methyl (DEACM)-caged CQ and HCQ derivatives as visible-light-activated autophagy inhibitors. Selective caging of the aliphatic amine suppressed biological activity in the dark and enabled rapid release of the parent drugs upon illumination. The lead compound

Indexed as

Antineoplastic AgentsAutophagyChloroquineLightNeoplastic Stem CellsAnimalsCell Line, TumorHumansMiceAntineoplastic AgentsChloroquine

Identifiers

PMID41873455
PMCPMC13097079

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.