Evidence map›Paper›PMID 41874118›Full record

ArticleJournal of xenobiotics2026

Enzyme-Targeted Antiproliferative Effects of Novel Indole-Acrylamide Xenobiotics Acting on Cyclooxygenase Pathways.

Mohammed Hawash, Benay Mahmutoğlu, Murad Abualhasan, Deniz Cansen Kahraman, Sultan Nacak Baytas

Abstract read
In one paragraph

Article in Journal of xenobiotics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mohammed HawashDepartment of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, An-Najah National University, Nablus 00433, Palestine.ORCID 0000-0001-5640-9700
Benay MahmutoğluDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara 06330, Turkey.
Murad AbualhasanDepartment of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, An-Najah National University, Nablus 00433, Palestine.ORCID 0000-0002-2083-856X
Deniz Cansen KahramanCancer Systems Biology Laboratory, Department of Health Informatics, Graduate School of Informatics, Middle East Technical University, Ankara 06800, Turkey.ORCID 0000-0002-3381-5463
Sultan Nacak BaytasDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara 06330, Turkey.ORCID 0000-0002-9929-6467

Funding

Scientific and Technological Research Council of Turkey program 2209-A
6 · The paper itself

Abstract

The indole scaffold is common in natural products and bioactive compounds, including anti-cancer and anti-inflammatory medicines. In this work, a series of indole-acrylamide derivatives was synthesized, and their antiproliferative and anti-inflammatory effects were evaluated on COX enzymes and against a panel of cancer cell lines. All the final compounds were characterized via HRMS and (

Indexed as

cancercell linesCOXindolemolecular dockingselectivity

Identifiers

PMID41874118
PMCPMC13010604

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.