Evidence map›Paper›PMID 41874350›Full record

ArticleNeuropathology : official journal of the Japanese Society of Neuropathology2026

DNA Virus Detection in Olfactory Neuroblastomas Using Targeted Enrichment NGS.

Maria K Jauhiainen, Outi I Mielonen, Aaro Haapaniemi, Maria Söderlund-Venermo, Jaana Hagström, Maria F Perdomo, Saku T Sinkkonen, Antti A Mäkitie

Abstract read
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In one paragraph

Article in Neuropathology : official journal of the Japanese Society of Neuropathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria K JauhiainenDepartment of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0003-2310-039X
Outi I MielonenDepartment of Virology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Aaro HaapaniemiDepartment of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Maria Söderlund-VenermoDepartment of Virology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Jaana HagströmDepartment of Pathology, Helsinki University Hospital, Helsinki, Finland.
Maria F PerdomoDepartment of Virology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Saku T SinkkonenDepartment of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Antti A MäkitieDepartment of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0002-0451-2404

Funding

Finska LäkaresällskapetHelsinki University Hospital Research TYH2024327Kirsti and Tor Johansson Heart and Cancer FoundationSigrid Jusélius FoundationThe Finnish Medical Foundation 7805
6 · The paper itself

Abstract

A variety of malignancies can be found in the sinonasal tract including the nasal cavity, paranasal sinuses, and skull base. Many of these are attributed to viruses, for example, carcinomas with the presence of transcriptionally active high-risk human papillomavirus, as well as Epstein-Barr virus associated malignant lymphoepithelial carcinoma and haematolymphoid neoplasias. Olfactory neuroblastoma (ONB) is a rare malignant tumor of the olfactory fossa with an unknown etiology. We present the first comprehensive virus study of ONB. By targeted next-generation sequencing for 41 DNA viruses, we investigated the presence of papillomaviruses, herpesviruses, polyomaviruses, and parvoviruses, among others, in 12 ONBs. In addition, herpesvirus presence was evaluated by qPCR. Low-risk HPV6 was detected in one sample. Human endogenous retroviruses were positive in all samples, supporting successful library preparation and sequencing, considered as an internal quality control. No other virus findings were observed. The present broad-scale virus study did not reveal abundant presence of viral DNA in ONB suggesting a limited viral role in its etiology. Nevertheless, our cohort exhibited a finding of low-risk HPV, which has been associated with increased risk of cancer progression of inverted sinonasal papilloma in the same anatomic site advocating for further research. Trial Registration: §31/07.03.2019.

Indexed as

DNA Tumor VirusesEsthesioneuroblastoma, OlfactoryNose NeoplasmsAdultAgedDNA, ViralFemaleHigh-Throughput Nucleotide SequencingHuman Papillomavirus VirusesHumansMaleMiddle AgedNasal CavityDNA, ViralDNA viruseshuman papillomavirus virusesolfactory esthesioneuroblastomapathologysequence analysis

Identifiers

PMID41874350
PMCPMC13011989

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.