Evidence mapPaperPMID 41874457Full record

Trial reportAmerican journal of physiology. Endocrinology and metabolism2026

Testosterone administration partially modulates gut microbiota responses to severe energy deficit.

Alex E Mohr, Claire E Berryman, Melissa N Harris, Alexander B Lawrence, Nabarun Chakraborty, Ross Campbell, George I Dimitrov, Aarti Gautam, Rasha Hammamieh, Harris R Lieberman and 3 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in American journal of physiology. Endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alex E MohrOak Ridge Institute for Science and Education, Oak Ridge, Tennessee, United States.ORCID 0000-0001-5401-3702
Claire E BerrymanMilitary Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States.ORCID 0000-0002-7841-8226
Melissa N HarrisPennington Biomedical Research Center, Baton Rouge, Louisiana, United States.
Alexander B LawrenceOak Ridge Institute for Science and Education, Oak Ridge, Tennessee, United States.ORCID 0009-0009-6967-359X
Nabarun ChakrabortyIntegrative Systems Biology Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States.
Ross CampbellIntegrative Systems Biology Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States.
George I DimitrovIntegrative Systems Biology Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States.
Aarti GautamIntegrative Systems Biology Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States.
Rasha HammamiehIntegrative Systems Biology Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States.ORCID 0000-0001-8643-6232
Harris R LiebermanMilitary Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States.ORCID 0000-0002-1519-0156
Jennifer C RoodPennington Biomedical Research Center, Baton Rouge, Louisiana, United States.ORCID 0000-0001-5848-2987
Stefan M PasiakosMilitary Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States.ORCID 0000-0002-5378-5820
J Philip KarlMilitary Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States.ORCID 0000-0002-5871-2241

Funding

Interdisciplinary Systems-based Training for Precision NutritionT32DK137525 · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · 2025 to 2025
$499k
DOD | OSD | Defense Technical Information Center (ADD) W81XWH-14-1-0335DOD | OSD | Defense Technical Information Center (ADD) W81XWH-17-2-0026DOE | Oak Ridge Institute for Science and Education (ORISE)HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) T32DK137525Military Operational Medicine Research Program (MOMRP) Joint Program Committee-5NIDDK NIH HHS T32 DK137525
6 · The paper itself

Abstract

Severe diet- and exercise-induced energy deficit (SED) suppresses androgen production in healthy men, altering metabolism and driving muscle loss. The gut microbiota modulates host metabolism, yet the community's response to SED and any role of androgen hormones are unclear. Herein, healthy, physically active men were randomized to receive 200 mg/wk testosterone enanthate (

Indexed as

AndrogensEnergy IntakeEnergy MetabolismGastrointestinal MicrobiomeTestosteroneAdultFatty Acids, VolatileFecesHumansMaleYoung AdultAndrogensFatty Acids, VolatileTestosteronetestosterone enanthateanabolichypocalorichypogonadismmetagenomicssemistarvation

Identifiers

PMID41874457
PMCPMC13256601

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.