ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2026
Hemodynamic rescue after blast injury: intravenous administration outperforms intramuscular vasopressin in a swine model.
Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHemorrhage remains the leading preventable cause of trauma mortality. Blast trauma combines primary blast effects with complex secondary and tertiary injuries, precipitating profound hemodynamic instability and microcirculatory disruption. While intramuscular (IM) arginine vasopressin (AVP) stabilizes arterial pressure in isolated hemorrhagic shock, vasopressin’s efficacy in blast-associated hemorrhagic shock is unknown.
methodsIn a randomized, blinded study, 22 swine underwent femoral blast injury and controlled class II hemorrhage. Animals received IM AVP 40 U (two doses 60 min apart due to short half-life and transient effects; n = 5), IM terlipressin 2 mg (n = 5), intravenous (IV) terlipressin 2 mg (n = 5), or saline control (n = 7). All subjects received a 500 mL autologous whole blood transfusion and were observed for 120 min. The primary outcome was systolic arterial pressure (SAP). Secondary outcomes included systemic vascular resistance index (SVRI), cardiopulmonary and metabolic variables, and serum AVP to assess IM uptake.
resultsIV terlipressin rapidly stabilized hemodynamics, increasing SAP (mean difference 24 mmHg, p = 0.01) and SVRI (mean difference 44593 dynes·s·cm⁻⁵·kg, p = 0.004) versus controls, and increased mixed venous oxygen saturation and urine output. Respiratory and metabolic variables were similar across groups. Neither IM AVP nor IM terlipressin generated a meaningful pressor response. IM AVP absorption was profoundly variable and did not reliably translate into hemodynamic stabilization; only one animal demonstrated both high systemic uptake and a sustained response.
conclusionsIn blast-associated hemorrhagic shock, IV terlipressin provided consistent hemodynamic stabilization, whereas IM vasopressin analogues were unreliable, highlighting a critical limitation of the IM route in blast pathophysiology. REGISTRY: Preclinicaltrials.eu, PCT ID: PCTE0000548, Registration date: 30 October 2024.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.