Evidence map›Paper›PMID 41874745›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026

Joint nausea and fatigue profiles during chemotherapy identify patients with a higher symptom burden.

Komal P Singh, Bruce A Cooper, Kathryn Ruddy, Keenan Pituch, Felipe Batalini, Steven M Paul, Marilyn Hammer, Yvette P Conley, Jon D Levine, Christine Miaskowski

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Komal P SinghMayo Clinic Cancer Center, Phoenix, AZ, USA.
Bruce A CooperDepartment of Physiological Nursing, School of Nursing, University of California, 490 Illinois Street, Floor 12, San Francisco, CA , 94143-0610, USA.
Kathryn RuddyMayo Clinic Cancer Center, Rochester, MN, USA.
Keenan PituchEdson College of Nursing and Health Innovation, Arizona State University, Phoenix, AZ, USA.
Felipe BataliniMayo Clinic Cancer Center, Phoenix, AZ, USA.
Steven M PaulDepartment of Physiological Nursing, School of Nursing, University of California, 490 Illinois Street, Floor 12, San Francisco, CA , 94143-0610, USA.
Marilyn HammerDana Farber Cancer Institute, Boston, MA, USA.
Yvette P ConleySchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
Jon D LevineSchool of Medicine, University of California, San Francisco, CA, USA.
Christine MiaskowskiDepartment of Physiological Nursing, School of Nursing, University of California, 490 Illinois Street, Floor 12, San Francisco, CA , 94143-0610, USA. chris.miaskowski@ucsf.edu.

Funding

Symptoms Clusters in Oncology Patients Receiving ChemotherapyR01CA134900 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, MIASKOWSKI, CHRISTINE A. · 2009 to 2014
$5.9M
NCI NIH HHS CA134900NCI NIH HHS R01 CA134900
6 · The paper itself

Abstract

purposeIdentify subgroups of oncology patients with distinct joint chemotherapy-induced nausea (CIN) AND morning fatigue profiles and distinct joint CIN AND evening fatigue profiles, as well as modifiable and non-modifiable risk factors.

methodsOncology patients receiving chemotherapy completed self-report questionnaires that provided information on demographic and clinical characteristics, as well as on CIN and morning and evening fatigue. The three symptoms were assessed six times over two cycles of chemotherapy. Joint latent class profile analyses (LCPA) were performed to identify subgroups of patients with distinct joint symptom profiles. Parametric and non-parametric tests were used to evaluate for differences in modifiable and non-modifiable risk factors among the profiles.

resultsFive and four subgroups were identified with distinct joint CIN and morning fatigue and distinct joint CIN and evening fatigue profiles, respectively. Risk factors associated with membership in the worse profiles included younger age, lower annual household income, high comorbidity burden, lower functional status, self-reported diagnosis of depression, and higher levels of neuropsychological and gastrointestinal symptoms.

conclusionsAcross both LCPAs, 60% of the sample reported CIN with occurrence rates that ranged from approximately 30% to 90%. In addition, wide variations were found in both morning and evening fatigue severity scores depending on the distinct profile. These initial findings suggest that CIN co-occurs with both morning and evening fatigue. The co-occurrence of CIN and fatigue may be related to shared biological mechanisms that warrant evaluation in future studies.

Indexed as

Antineoplastic AgentsFatigueNauseaNeoplasmsAdultAgedAge FactorsFemaleHumansLatent Class AnalysisMaleMiddle AgedRisk FactorsSelf ReportSeverity of Illness IndexSurveys and QuestionnairesAntineoplastic AgentsCancerChemotherapyFatigueMultimorbidityNausea

Identifiers

PMID41874745
PMCPMC13013181

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.