ArticleMolecular biology reports2026
Skin wound healing effects of Pectinodesmus javanensis extract through activation of TGF-β/SMAD signaling pathway.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
5 authors.
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Abstract
backgroundThis study aimed to evaluate the wound-healing potential of Pectinodesmus javanensis extract (PJE) in dermal fibroblasts, with particular emphasis on extracellular matrix (ECM) regeneration mediated by the transforming growth factor-β (TGF-β)/SMAD signaling pathway. METHODS AND
resultsThe phytochemical profile of PJE was assessed by total phenolic and flavonoid contents and DPPH and ABTS radical-scavenging activities. PJE contained 1.5 mg gallic acid equivalents (GAE)/g dry matter (DM) of phenolics and 4.1 µg quercetin equivalents (QE)/g DM of flavonoids, with DPPH and ABTS scavenging activities of 32.5% and 34.6%. PJE inhibited collagenase and elastase activities by 79.3% and 77.4%, comparable to lutein (78.9% and 77.3%), and enhanced fibroblast migration by 51.8% in scratch-wound assays, while lutein increased migration by 60.3%. These effects were associated with improved cellular organization, evidenced by increased fluorescence intensities of DAPI (31.2% and 30.1%), ZO-1 (21.6% and 13.4%), and F-actin (16.9% and 11.1%). At the molecular level, PJE upregulated TGF-β, SMAD2/3, and COL1A1 while suppressing MMP-1 expression by 58.3%, whereas lutein reduced MMP-1 by 65.7%.
conclusionPJE promotes fibroblast migration and regulates ECM-related factors in vitro via the TGF-β/SMAD signaling pathway. These findings support the potential use of Pectinodesmus javanensis–derived compounds, including lutein, as functional ingredients for cosmetic and pharmaceutical applications in skin regeneration.
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