ArticleDiabetes therapy : research, treatment and education of diabetes and related disorders2026
Clinical and Metabolic Characteristics of Spontaneous Remission in Type 2 Diabetes: A Real-World Study from South India.
Article in Diabetes therapy : research, treatment and education of diabetes and related disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis study aimed to evaluate clinical characteristics and outcomes of individuals with type 2 diabetes (T2D) who achieved spontaneous remission without structured intervention.
methodsWe examined electronic medical records of 243,400 adults with T2D attending a tertiary care center in India between 1993 and 2018. Spontaneous remission was defined as achieving glycated hemoglobin (HbA1c) < 6.5% for at least 3 months without glucose-lowering medication in those who earlier had HbA1c ≥ 6.5%. A matched group without remission was selected for comparison.
resultsAmong 243,400 individuals with T2D, 275 (0.11%) achieved spontaneous remission. Remission occurred in 0.34% of individuals with baseline HbA1c < 7.0%, 0.13% with HbA1c 7.0-7.9%, and 0.08% with HbA1c ≥ 8.0%. Diabetes recurred in 69%, 80%, and 87% of these respective groups, after a median remission duration of 2.1 years. Sustained remission was observed in 55 individuals (0.02%). Individuals who achieved remission were older, had lower body weight and glucose levels, shorter duration, higher C-peptide, and greater physical activity. Relapse was associated with higher body weight and postprandial glucose levels. Individuals who had longer remission had greater weight loss.
conclusionSpontaneous remission of T2D is rare and mostly transient. Higher baseline HbA1c predicts relapse, while sustained weight loss is strongly associated with long-term remission.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.