Evidence map›Paper›PMID 41875154›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Fab-Fc and Fab-Fab interactions of variable strength and valency contribute to the high concentration viscosity of IgG

Joel Heisler, Jennifer L Hofmann, Zhenyu Tan, Jonathan Zarzar, Saeed Izadi, Paul J Carter

Abstract read
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joel HeislerDepartment of Antibody Engineering, Genentech, Inc., South San Francisco, CA 94080.ORCID 0000-0002-2703-3035
Jennifer L HofmannDepartment of AI for Drug Discovery, Genentech, Inc., South San Francisco, CA 94080.ORCID 0000-0003-2799-3172
Zhenyu TanDepartment of Antibody Engineering, Genentech, Inc., South San Francisco, CA 94080.ORCID 0000-0001-6491-5806
Jonathan ZarzarDepartment of Pharmaceutical Development, Genentech, Inc., South San Francisco, CA 94080.
Saeed IzadiDepartment of Pharmaceutical Development, Genentech, Inc., South San Francisco, CA 94080.ORCID 0000-0003-4206-8559
Paul J CarterDepartment of Antibody Engineering, Genentech, Inc., South San Francisco, CA 94080.ORCID 0000-0001-7854-062X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The variable domains in Fab regions are well-established contributors to high concentration viscosity of IgG, primarily through charge and hydrophobic interactions. In contrast, the roles of the Fc and the number of self-interacting sites (valency) are less well understood. Here, we investigate the relative contributions of Fab-Fab and Fab-Fc interactions to high concentration viscosity for a diverse panel of 20 IgG

Indexed as

Immunoglobulin Fab FragmentsImmunoglobulin Fc FragmentsImmunoglobulin GHumansModels, MolecularProtein BindingViscosityImmunoglobulin Fab FragmentsImmunoglobulin Fc FragmentsImmunoglobulin Gantibody viscositycoarse-grained modelingintermolecular interactionssubcutaneous delivery

Identifiers

PMID41875154
PMCPMC13037845

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.