Evidence map›Paper›PMID 41875310›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Tumor-Derived Exosomes Deliver Membrane-Bound Fgl2 to Activate FcγRIIB-Mediated Immunosuppression in Myeloid-Derived Suppressor Cells.

Fenglin Lin, Dingqin Cai, Chunli Jian, Yaxian Qi, Linpeng Zheng, Qiao Yang, Longyao Zhang, Diangang Chen, Lingchen Li, Ping Cai and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fenglin LinDepartment of Oncology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Dingqin CaiDepartment of Hematology and Oncology, 921 Hospital of Joint Logistics Support Force of PLA(the Second Affiliated Hospital of Hunan Normal University), Changsha, China.
Chunli JianDepartment of Oncology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Yaxian QiDepartment of Oncology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Linpeng ZhengDepartment of Oncology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Qiao YangDepartment of Oncology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Longyao ZhangDepartment of Oncology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Diangang ChenDepartment of Oncology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Lingchen LiDepartment of Oncology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Ping CaiDepartment of Oncology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Lingyou SunDepartment of Oncology, Xinqiao Hospital, Army Medical University, Chongqing, China.
Luping ZhangSchool of Pharmaceutical Engineering, Chongqing Chemical Industry College, Chongqing, China.
Jianguo SunDepartment of Oncology, Xinqiao Hospital, Army Medical University, Chongqing, China.ORCID https://orcid.org/0000-0002-4855-3689

Funding

Chongqing Medical Leading Talent Project YXLJ202405National Natural Science Foundation of China 81602688National Natural Science Foundation of China 82172670National Natural Science Foundation of China 82473261Noncommunicable Chronic Diseases-National Science and Technology Major Project 2023ZD0502100
6 · The paper itself

Abstract

Myeloid-derived suppressor cells (MDSCs) play a pivotal role in establishing an immunosuppressive tumor microenvironment (TME), yet the mechanisms underlying their functional activation remain incompletely defined. Here, we identify the Fgl2-FcγRIIB signaling axis as a critical mediator of MDSC-driven immune evasion across solid tumors. Analysis of clinical specimens revealed that Fgl2 expression is significantly elevated in tumor tissues and inversely correlates with CD8

Indexed as

ExosomesFibrinogenMyeloid-Derived Suppressor CellsNeoplasmsReceptors, IgGAnimalsHumansImmune ToleranceMiceMice, Inbred C57BLTumor MicroenvironmentFGL2 protein, humanFgl2 protein, mouseFibrinogenReceptors, IgGFgl2‐FcγRIIB axisimmunotherapyMDSCsTEXTME

Identifiers

PMID41875310
PMCPMC13292161

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.