Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
13 authors.
Meihui YiDepartment of Chemistry, Brandeis University, Waltham, Massachusetts 02454, United States.ORCID 0000-0002-1912-1043
Jiaqi GuoMicrobial Sciences Institute, Yale University, West Haven, Connecticut 06516, United States.
Ayisha ZiaDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35233, United States.
Wangbiao GuoMicrobial Sciences Institute, Yale University, West Haven, Connecticut 06516, United States.ORCID 0000-0001-5398-4910
Shoichi TachiyamaMicrobial Sciences Institute, Yale University, West Haven, Connecticut 06516, United States.
Gabriel Ashton-RickardtDepartment of Chemistry, Brandeis University, Waltham, Massachusetts 02454, United States.
Weiyi TanDepartment of Chemistry, Brandeis University, Waltham, Massachusetts 02454, United States.ORCID 0000-0001-5316-8278
Yuchen QiaoDepartment of Chemistry, Brandeis University, Waltham, Massachusetts 02454, United States.ORCID 0009-0008-6401-6980
Yinan GongDepartment of Immunology, University of Pittsburgh and UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania 15232, United States.
Edward H EgelmanDepartment of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, United States.ORCID 0000-0003-4844-5212
Jun LiuMicrobial Sciences Institute, Yale University, West Haven, Connecticut 06516, United States.
Fengbin WangDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35233, United States.
Bing XuDepartment of Chemistry, Brandeis University, Waltham, Massachusetts 02454, United States.ORCID 0000-0002-4639-387X
Funding
Cryo-EM of Helical Protein and Nucleoprotein Polymers at Near Atomic ResolutionR35GM122510 · NIGMS · UNIVERSITY OF VIRGINIA · PI EDWARD H. EGELMAN · 2017 to 2026
$7.3M
Structure-Function Relationships in the Spirochetal Flagellar MotorR01AI087946 · NIAID · YALE UNIVERSITY · PI LIU, JUN · 2010 to 2025
$6.6M
Subcellular Enzyme-instructed self-assembly for molecular anticancer nanomedicinesR01CA142746 · NCI · BRANDEIS UNIVERSITY · PI Bing Xu · 2010 to 2026
$6.4M
Functional and Structural Analysis of the Dot/Icm Type IVB Secretion MachineR01AI152421 · NIAID · YALE UNIVERSITY · PI LIU, JUN, ROY, CRAIG R. · 2020 to 2024
$2.9M
Molecular Electron Microscopy Core Facility ImprovementsG20RR031199 · NCRR · UNIVERSITY OF VIRGINIA · PI SHUPNIK, MARGARET A · 2010 to 2010
$2.0M
High-throughput electron cryo-microscopeS10OD023603 · OD · YALE UNIVERSITY · PI SIGWORTH, FREDERICK J · 2018 to 2018
$1.9M
Understanding and using microbial conductive nanowiresR00GM138756 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WANG, FENGBIN · 2022 to 2024
$895k
Selectively eliminating residual human induced pluripotent stem cells (iPSCs) in cell mixtures for cell therapyR21EY036512 · NEI · BRANDEIS UNIVERSITY · PI XU, BING · 2024 to 2025
$375k
Understanding and using microbial conductive nanowiresK99GM138756 · NIGMS · UNIVERSITY OF VIRGINIA · PI WANG, FENGBIN · 2021 to 2022
Programmed lytic cell death, including pyroptosis and necroptosis, involves intracellular enzymes that form membrane-rupturing pores. Tumor-associated ectoenzymes such as alkaline phosphatase (ALP), however, offer the potential to initiate lytic death extrinsically. Here, we design a phospho-biphenyl-capped peptide precursor that is selectively dephosphorylated by ALP on cancer cell surfaces, triggering enzyme-instructed peptide self-assembly (EISA) into in situ peptide filaments. These supramolecular filaments physically breach the plasma membrane, overwhelm ESCRT-dependent membrane repair, and induce catastrophic calcium influx, cytoskeletal collapse, and organelle dysfunction. While cryo-EM uncovers 2.5-2.9 Å resolution details of ordered dimeric packing that underlies their mechanical rigidity and membrane-rupturing capability, cryo-electron tomography (cryo-ET) reveals the filament penetration of the plasma membrane in live cells. By reprogramming ALP from an immune checkpoint ectoenzyme into a pro-death catalyst, this work establishes a molecular mechanism linking enzymatic catalysis to supramolecular order and membrane failure. More broadly, it outlines a supramolecular chemical-biology framework in which enzyme-triggered assemblies function as programmable executors of cell death.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Cryo-Structural Insights into Enzymatic Peptide Self-Assembly Driving Extrinsic Lytic Cell Death. · full record | Socratic