ArticleCurrent biology : CB2026
Drift of positional identity drives reproductive aging in a long-lived regenerative animal.
Article in Current biology : CB, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Regeneration: A planarian DIY fertility restoration guide.Current biology : CB · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Most animals experience irreversibly declining health with advancing age, in part due to limitations in cell turnover and the accumulation of damage. The highly regenerative planarian Schmidtea mediterranea has abundant pluripotent stem cells that drive continuous cell turnover, yet it experiences an age-related loss of fertility, which can be restored through regeneration. We find that the source of planarian age-related infertility lies in the female reproductive system, accompanied by the formation of posterior ectopic ovaries and disrupted accessory reproductive structures, which are restored during regeneration. We further observe that the Notum/Wnt signaling gradient, which determines anterior-posterior polarity in planarians, is shifted posteriorly with age and that manipulating this gradient by RNAi was able to slow down or accelerate reproductive aging. These results indicate that in addition to a healthy stem cell pool, tissue polarity must be maintained to mitigate age-related decline and that resetting positional information could be a promising mechanism to promote tissue rejuvenation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.