Evidence map›Paper›PMID 41876146›Full record

ArticleRMD open2026

Pericoronary fat attenuation and its association with atherosclerosis in rheumatoid arthritis compared with controls: a cross-sectional study.

George A Karpouzas, Frederik Cosedis Enevoldsen, Panteha Rezaeian, Dzenan Masic, Matthew J Budoff, Ellen-Margrethe Hauge, Sarah R Ormseth

Abstract read
In one paragraph

Article in RMD open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

George A KarpouzasHarbor-UCLA Medical Center, Torrance, California, USA gkarpouzas@lundquist.org.ORCID 0000-0003-1065-1563
Frederik Cosedis EnevoldsenDepartment of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.
Panteha RezaeianHarbor-UCLA Medical Center, Torrance, California, USA.
Dzenan MasicDepartment of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.
Matthew J BudoffHarbor-UCLA Medical Center, Torrance, California, USA.
Ellen-Margrethe HaugeDepartment of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.
Sarah R OrmsethHarbor-UCLA Medical Center, Torrance, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe compared mean and artery-specific pericoronary adipose tissue attenuation (PCATa) between rheumatoid arthritis (RA) patients and controls and examined whether clinical factors and coronary plaque burden were associated with PCATa similarly in both groups. We also explored differences in PCATa around plaque-free arteries between RA and controls.

methodsThis cross-sectional analysis included 147 patients with RA and 118 age-matched and sex-matched controls with complete coronary CT angiography data. PCATa and plaque counts (total, non-calcified, mixed or calcified) were assessed at a single time point. Models adjusted for age, sex, cardiovascular risk factors and epicardial adipose tissue volume.

resultsMean and artery-specific PCATa around right coronary (RCA) and left circumflex (LCx) arteries were higher in RA than controls (B=0.35 (95% CI 0.12 to 0.58), B=0.39 (95% CI 0.14 to 0.63) and B=0.25 (95% CI 0.03 to 0.48), respectively). Mean PCATa was higher in males than females (p<0.01). Age and dyslipidaemia influenced PCATa differently in RA versus controls (p for interaction=0.032 and 0.021). Mean and LCx-PCATa were associated with total and mixed plaque counts in RA but not in controls (p for interaction=0.040 and 0.021, respectively). Per-artery PCATa did not differ between RA and controls without atherosclerosis. Among participants with atherosclerosis, PCATa around plaque-free LCx and RCA vessels was higher in RA than controls (p<0.05).

conclusionsPCATa was higher in RA than controls. Mean PCATa was higher in men and associated with coronary atherosclerosis in RA but not in controls. PCATa differences around plaque-free LCx and RCA vessels between RA and controls were observed among participants with plaque elsewhere.

Indexed as

Adipose TissueArthritis, RheumatoidAtherosclerosisCoronary Artery DiseaseCoronary VesselsAgedCase-Control StudiesComputed Tomography AngiographyCoronary AngiographyCross-Sectional StudiesEpicardial Adipose TissueFemaleHumansMaleMiddle AgedPlaque, AtheroscleroticArthritis, RheumatoidAtherosclerosisCardiovascular Diseases

Identifiers

PMID41876146
PMCPMC13034213

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.