Evidence map›Paper›PMID 41876945›Full record

ArticleComprehensive Physiology2026

A Single Bout of Aerobic Exercise Increases Neuronal Extracellular Vesicle-Derived Insulin Signaling Biomarkers in Adults With Cardiometabolic Risk.

Steven K Malin, Daniel J Battillo, Michal S Beeri, Maja Mustapic, Dimitrios Kapogiannis

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Comprehensive Physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05853913 nacompletednot on this map

Impact of Acute Exercise on Brain Insulin Sensitivity in Middle-aged to Older Adults

TypeinterventionalSponsorRutgers, The State University of New JerseyRan2023 to 2025Enrolled16ConditionsAging, Obesity, Insulin Resistance, CognitionArmsExercise
NCT07675499 phase2 / phase3recruitingnot on this map

Effects of Intranasal Insulin Plus Exercise Training on Brain Blood Flow, Neuronal Insulin Signaling, and Cognition in Adults With Type 2 Diabetes

TypeinterventionalSponsorRutgers, The State University of New JerseyRan2026 to 2029Enrolled60ConditionsType 2 Diabetes, Insulin Sensitivity/Resistance, Cognition, Brain Blood FlowArmsIntranasal Insulin, Intranasal Placebo, High Intensity Exercise
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Steven K MalinDepartment of Kinesiology and Health, Rutgers University, New Brunswick, New Jersey, USA.ORCID 0000-0002-7360-6711
Daniel J BattilloDepartment of Kinesiology and Health, Rutgers University, New Brunswick, New Jersey, USA.
Michal S BeeriInstitute for Health, Health Care Policy and Aging Research, Rutgers University, New Brunswick, New Jersey, USA.
Maja MustapicNational Institute on Aging, Baltimore, Maryland, USA.
Dimitrios KapogiannisNational Institute on Aging, Baltimore, Maryland, USA.ORCID 0000-0003-2181-3118

Funding

Brain Health Institute, Rutgers UniversityNIDDK NIH HHS R01DK133598-01A1
6 · The paper itself

Abstract

Exercise may lower Alzheimer's Disease and Related Dementia (ADRD) risk. While insulin has been proposed to benefit cognition, the effect of exercise on neuronal insulin signaling in humans is unclear. PURPOSE: We tested the hypothesis that a single bout of aerobic exercise would raise insulin signaling mediators from plasma-derived neuronal extracellular vesicles (nEVs).

methodsFifteen sedentary adults with obesity (12F; ~56y; ~31 kg/m

resultsExercise tended to lower glucose tAUC

conclusionsA single bout of aerobic exercise increases some nEV-associated insulin signaling phosphoproteins in people with cardiometabolic risk. Additional work is warranted to determine if changes in brain insulin signaling translate to lower ADRD risk. CLINICAL TRIALS REGISTRATION: NCT05853913.

Indexed as

Alzheimer's diseasebrain insulin resistancephysical activitytype 2 diabetes

Identifiers

PMID41876945
PMCPMC13013089

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.