ArticleBMC medicine2026
Clinical epidemiology and risk prediction of unsuccessful treatment outcomes in pulmonary tuberculosis with diabetes mellitus.
Article in BMC medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundThis study aims to characterize the epidemiological and clinical features of pulmonary tuberculosis with diabetes mellitus (PTB-DM), identify risk factors for unsuccessful treatment outcomes, and develop predictive models to aid in outcome assessment for these patients.
methodsClinical data from 3886 pulmonary tuberculosis (PTB) cases treated at Liuzhou People's Hospital Affiliated to Guangxi Medical University between July 2017 and December 2023 were analyzed. A case-control study was conducted to investigate the epidemiological and clinical profiles of PTB-DM. A retrospective cohort study and the LASSO-Logistic regression model were employed to identify independent risk factors for unsuccessful treatment outcomes, and a risk nomogram prediction model was developed to assess the predictive performance of the model.
resultsFrom 2017 to 2023, the rates of diabetes mellitus among pulmonary tuberculosis patients were 7.14%, 9.44%, 13.96%, 12.37%, 11.78%, 14.45%, and 19.63%, respectively. The proportion of pulmonary tuberculosis with diabetes mellitus showed a significant upward trend (P < 0.001). Various parameters including bacteriological positivity rate, sputum smear positivity rate at baseline, secondary pulmonary tuberculosis,and clinical symptoms like hemoptysis and chest pain, as well as imaging findings such as pulmonary cavity and pleural effusion, and unsuccessful treatment outcomes were all notably higher in PTB-DM patients compared to non PTB-DM patients (P < 0.05). Risk factors for unsuccessful outcomes in PTB-DM patients included being aged 65 or older (OR = 7.334, 95% CI: 2.654-23.136), hemoptysis (OR = 9.245, 95% CI: 3.411-27.464), positive sputum smear at baseline (OR = 3.774, 95% CI: 1.451-10.388), pulmonary cavity (OR = 3.850, 95% CI: 1.426-10.721), elevated CKMB levels (OR = 1.074, 95% CI: 1.014-1.136), elevated ESR (OR = 1.049, 95% CI: 1.025-1.077), and elevated HbAlc (OR = 1.352, 95% CI: 1.105-1.678), while higher ALB levels (OR = 0.874, 95% CI: 0.778-0.977) was a protective factor. A nomogram model incorporating these variables demonstrated high discriminative ability (AUC = 0.959, 95% CI: 0.931-0.987), with good calibration as assessed by the Hosmer-Lemeshow goodness-of-fit test (P = 0.474).
conclusionsPulmonary tuberculosis patients with diabetes mellitus exhibit more severe clinical manifestations and a higher risk of unsuccessful treatment outcomes compared to those without diabetes. The nomogram model developed based on selected predictors demonstrates excellent predictive performance and can assist clinicians in early risk stratification and individualized management of PTB-DM patients.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.