Evidence map›Paper›PMID 41877218›Full record

ArticleBMC research notes2026

Micronuclei and sister chromatid exchange in lymphocytes from physicians exposed to ionizing radiation.

Juan Pablo Meza-Espinoza, Liliana Itzel Patrón-Baro, Nayeli Nieto-Marín, Alberto Kousuke De la Herrán-Arita, Claudia Desireé Norzagaray-Valenzuela, Tomás Adrián Carrillo-Cázares, Salvador Cervín-Serrano, José Johanatan Valdez-Sandoval, Juan Fidel Osuna-Ramos, Verónica Judith Picos-Cárdenas

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In one paragraph

Article in BMC research notes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Juan Pablo Meza-EspinozaFacultad de Medicina Matamoros, Universidad Autónoma de Tamaulipas, Matamoros, Tamps, México.
Liliana Itzel Patrón-BaroMaestría en Ciencias en Biomedicina Molecular, Facultad de Medicina, Universidad Autónoma de Sinaloa, Culiacán, Sin, México.
Nayeli Nieto-MarínMaestría en Ciencias en Biomedicina Molecular, Facultad de Medicina, Universidad Autónoma de Sinaloa, Culiacán, Sin, México.
Alberto Kousuke De la Herrán-AritaLaboratorio de Genética, Facultad de Medicina, Universidad Autónoma de Sinaloa, Culiacán, Sin, México.
Claudia Desireé Norzagaray-ValenzuelaFacultad de Biología, Universidad Autónoma de Sinaloa, Culiacán, Sin, México.
Tomás Adrián Carrillo-CázaresLaboratorio de Genética, Facultad de Medicina, Universidad Autónoma de Sinaloa, Culiacán, Sin, México.
Salvador Cervín-SerranoCentro de Investigación en Docencia en Ciencias de la Salud, Universidad Autónoma de Sinaloa, Culiacán, Sin, México.
José Johanatan Valdez-SandovalFacultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, Culiacán, Sin, México.
Juan Fidel Osuna-RamosLaboratorio de Genética, Facultad de Medicina, Universidad Autónoma de Sinaloa, Culiacán, Sin, México.
Verónica Judith Picos-CárdenasLaboratorio de Genética, Facultad de Medicina, Universidad Autónoma de Sinaloa, Culiacán, Sin, México. veronicapicos@uas.edu.mx.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveOccupational exposure to ionizing radiation is a known risk factor for genomic instability. This study evaluated whether physicians occupationally exposed to ionizing radiation exhibit higher frequencies of chromosomal alterations compared to unexposed hospital workers, utilizing micronuclei and sister chromatid exchanges as biomarkers.

methodsPeripheral blood samples were analyzed from 50 participants: 25 physicians exposed to ionizing radiation (radiologists) and a control group of 25 sex- and age-matched hospital staff with no history of occupational exposure. The cytokinesis-block micronucleus and sister chromatid exchange assays were employed to assess genomic instability.

resultsNo significant differences were observed in hematological parameters between the two groups. However, the frequencies of both micronuclei and sister chromatid exchanges were significantly higher in the exposed physicians compared to the unexposed control group. Chronic occupational exposure to ionizing radiation is associated with measurable signs of genomic instability. These findings highlight the necessity of implementing regular biomonitoring programs for exposed medical personnel to detect early genetic alterations and mitigate potential health risks.

Indexed as

LymphocytesMicronuclei, Chromosome-DefectiveOccupational ExposurePhysiciansRadiation, IonizingSister Chromatid ExchangeAdultFemaleGenomic InstabilityHumansMaleMicronucleus TestsMiddle AgedBiomonitoringDNA damageGenomic instabilityIonizing radiationMicronucleiOccupational exposureSister chromatid exchange

Identifiers

PMID41877218
PMCPMC13134078

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.