ArticleNeuropsychiatric disease and treatment2026
The Effect of miR-1273d Between Chronic Childhood Stress and Positive Symptoms in Schizophrenia: A Preliminary Mediation Analysis.
Article in Neuropsychiatric disease and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: High disability and recurrence rates have driven researchers to explore the etiology and pathological processes of schizophrenia (SCZ). This study aimed to investigate the relationship between chronic childhood stress and positive symptoms in SCZ patients from the perspective of microRNA (miRNA) expression levels in peripheral blood. Patients and Methods: 80 SCZ patients and 80 sex- and age-matched healthy individuals were enrolled and assessed using Positive and Negative Syndrome Scale (PANSS) and Childhood Chronic Stress Questionnaire (CCSQ). The miRNA expression level were detected by Quantitative Real-Time PCR (qRT-PCR). Results: The area under the curve of combined receiver operating characteristic (ROC) curve for aberrantly expressed miRNAs was 0.958, with sensitivity and specificity of 0.838 and 0.963, respectively ( Conclusion: Differentially expressed miRNAs as predictors of psychopathological symptoms in SCZ patients may be potential biomarkers for SCZ diagnosis. Chronic childhood stress may regulate susceptibility gene expression and pathological processes of SCZ by affecting miRNA-1273d expression.
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