Evidence map›Paper›PMID 41878294›Full record

ReviewFrontiers in cellular neuroscience2025

Molecular and developmental insights into proprioceptive identity in the mesencephalic trigeminal nucleus neurons.

Pa Reum Lee, Seog Bae Oh

Abstract readReview
In one paragraph

Review in Frontiers in cellular neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Pa Reum LeeBrain Science Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea.
Seog Bae OhDepartment of Neurobiology and Physiology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mesencephalic trigeminal nucleus (MTN) contains trigeminal proprioceptive neurons, a unique class of primary sensory neurons with centrally located cell bodies and a developmental origin distinct from that of peripheral ganglion-derived spinal proprioceptors. MTN neurons have long been recognized for their morphological heterogeneity, but their functions were traditionally viewed as confined to the jaw jerk reflex and oromotor control, reflecting their predominant innervation of jaw-closing muscles. Recent single-cell transcriptomic studies have provided new insight into MTN neurons by uncovering molecular determinants of proprioceptive identity, revealing discrete transcriptional programs that underlie their developmental trajectories and functional specialization. While some subsets of MTN neurons share features with Group Ia and II proprioceptors, they are distinguished by characteristic molecular signatures, including the absence of

Indexed as

developmental originsdorsal root ganglionmasticationmesencephalic trigeminal nucleusoral sensorimotor controlpostnatal developmentproprioceptive primary sensory neurontranscriptional programs

Identifiers

PMID41878294
PMCPMC13006322

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.