Evidence map›Paper›PMID 41878569›Full record

Trial reportFrontiers in nutrition2026

Probiotic improves respiratory and gastrointestinal health, immune homeostasis, and gut microbiota composition in infants: a randomized controlled trial.

Mageswaran Uma Mageswary, Lan Hanglian, Pin Li, Rocky Vester Richmond, Yusof Azianey, Joo Shun Tan, Min-Tze Liong, Adli Ali, Mishaleni Vejayantheran, Jiang Hua and 4 more

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05794815 (Modulation of Gut Microbiota by Probiotic in Children With Respiratory Symptoms), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05794815 naunknown statusnot on this map

Modulation of Gut Microbiota by Probiotic in Children With Respiratory Symptoms

TypeinterventionalSponsorMin-Tze LIONGRan2023 to 2026Enrolled120ConditionsRespiratory Infection (for Example, Pneumonia, Bronchitis)ArmsProbiotic, Placebo
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mageswaran Uma Mageswary *School of Industrial Technology, Universiti Sains Malaysia, Gelugor, Pulau Pinang, Malaysia.
Lan Hanglian *National Technology Innovation Center for Dairy, Hohhot, China.
Pin LiDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University Health Science Center, Beijing, China.
Rocky Vester RichmondDepartment of Pediatrics, Universiti Kebangsaan Malaysia Medical Centre, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Yusof AzianeyKepala Batas Health Clinic, Kepala Batas, Pulau Pinang, Malaysia.
Joo Shun TanSchool of Industrial Technology, Universiti Sains Malaysia, Gelugor, Pulau Pinang, Malaysia.
Min-Tze LiongSchool of Industrial Technology, Universiti Sains Malaysia, Gelugor, Pulau Pinang, Malaysia.
Adli AliDepartment of Pediatrics, Universiti Kebangsaan Malaysia Medical Centre, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Mishaleni VejayantheranSchool of Industrial Technology, Universiti Sains Malaysia, Gelugor, Pulau Pinang, Malaysia.
Jiang HuaSchool of Nursery, Peking University Health Science Center, Beijing, China.
He JianNational Technology Innovation Center for Dairy, Hohhot, China.
Intan Juliana Abd HamidPrimary Immunodeficiency Diseases Group, Department of Clinical Medicine, Pusat Kanser Tun Abdullah Ahmad Badawi, Universiti Sains Malaysia, Kepala Batas, Pulau Pinang, Malaysia.
Fahisham TaibPaediatric Department, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Yumei ZhangDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University Health Science Center, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The early postnatal period is a critical window for shaping the gut microbiota, which plays a pivotal role in immune maturation, infection resistance, and metabolic programming. Disruptions to this process may predispose infants to infections and allergic or metabolic disorders. Probiotics such as Methods: In a 12-week, randomized, double-blind, placebo-controlled trial, 119 healthy infants were enrolled ( Results: Compared with placebo, Clinical trial registration: https://clinicaltrials.gov/study/NCT05794815?term=NCT05794815&rank=1, Identifier: NCT05794815.

Indexed as

Bifidobacterium infantisimmune homeostasisinfant gut microbiotamucosal immunityprobioticrespiratory tract infections

Identifiers

PMID41878569
PMCPMC13006235

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.